Seed Therapeutics, Eli Lilly to develop 'molecular glue' therapeutics

By The Science Advisory Board staff writers

November 13, 2020 -- Seed Therapeutics has entered into a research collaboration and license agreement with Eli Lilly to discover and develop new chemical entities that could produce therapeutic benefit via targeted protein degradation (TPD).

The TPD field targets hundreds of proteins that are known to be associated with human diseases but were previously thought to be undruggable. Seed Therapeutics, a subsidiary of BeyondSpring, has pioneered a strategy dubbed "molecular glue" to activate the protein degradation mechanism that is present in all cells to recognize and degrade the disease-causing protein. The molecular glue specifically focuses on new chemical entities with more drug-like chemical properties.

Lilly is giving Seed Therapeutics $10 million in upfront cash payments to fund research and a $10 million equity investment. Seed Therapeutics will also be eligible to receive up to approximately $780 million in potential preclinical and clinical development, regulatory, and commercial milestones. The firm may also receive tiered royalties on net sales of products that result from the collaboration. The transaction is subject to customary closing conditions, the firms said.

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