Proteomics
New molecular drivers of Parkinson's disease identified
A group of researchers at the Icahn School of Medicine at Mount Sinai have discovered new molecular drivers of Parkinson's disease (PD) and subsequently determined how they impact the function of genes involved in the disease. This was accomplished using a complex statistical technique called multiscale gene network analysis (MGNA). The results were published in Nature Communications on November 20.  Discuss
Is there a reproducibility problem with RNA-seq data?
Modern day technology has allowed scientists to analyze highly complex genomic data sets. However, with this comes increased challenges associated with reproducibility and misinterpretation of results from massive data sets. One such example, RNA sequencing (RNA-Seq), provides the ability to simultaneously measure gene expression levels of all genes in a sample in a single test.  Discuss
Scientists build a better brain map
Researchers at Cold Spring Harbor Laboratory published a new study in Cell, on October 17, that introduces barcoded anatomy resolved by sequencing (BARseq), the next generation of MAPseq.  Discuss
Study shows that Huntington's disease can be slowed by modifying brain cells
A new study led by researchers at UCLA published in Science Translational Medicine on October 16 found that Huntington's disease (HD) damages astrocytes at the early stages of the disease, contributing to neuropsychiatric symptoms.  Discuss
New CRISPR Cas13 system offers powerful antiviral protection
A first-of-its-kind study conducted by researchers at the Broad Institute of MIT and Harvard demonstrates that Cas13, a class 2 CRISPR system, can be used as an antiviral in cultured human cells. The research, published in Molecular Cell on October 10, suggests that the RNA-cutting enzyme can be programmed to detect and destroy RNA-based viruses.  Discuss
New molecular cause identified for neurodegeneration in Alzheimer's disease
A collaborative research effort uncovered evidence for a new molecular basis for neurodegeneration seen in patients with Alzheimer's disease. Researchers from Baylor College of Medicine and the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital published the study in Cell Reports on October 8.  Discuss
New research suggests circular RNAs are important for cardiac healing
Researchers from the Lewis Katz School of Medicine at Temple University describe how circular RNA fills a critical role during tissue repair after heart attacks, due to a unique ability to absorb harmful molecules. The study was published September 20 in Nature Communications.  Discuss
New populations of lung cells identified which could aid in the treatment of chronic respiratory diseases
New research confirms the existence of two new subpopulations interstitial macrophages (IM), which are crucial to the pulmonary immune system. Published in Nature Communications on August 3, researchers from the Immunophysiology Laboratory of the GIGA Institute at the University of Liege provide insights into the characterization of these IM.  Discuss
Success of immunotherapies increased in cancer patients through co-treatment with monoclonal antibodies
A new approach provides evidence that it is possible to break down the protective wall surrounding tumor cells, therefore making immunotherapies more effective in patients with a variety of cancers. This research, funded by Cancer Research UK, was published in the EBioMedicine on August 25th.  Discuss
Detecting HPV in women is improved with the aid of a new molecular approach
A new technique called HPV RNA-Seq can provide a second-line test in HPV-positive patients to reduce unnecessary colposcopies and even be used as a two-in-one test combining HPV typing with triage capabilities. Researchers from Institut Pasteur and the Pathogen Discovery Laboratory in Paris, France published their findings in The Journal of Molecular Diagnostics on August 12, 2019.  Discuss
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Conferences
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
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Conferences
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
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