Life Science Informatics
3D magnetic cell culture transforms cancer therapy screening
Traditional high-throughput drug screening in oncology routinely relies on 2D cell models, which inadequately recapitulate the physiologic context of cancer. With recent technological advancements, a novel method for magnetic 3D cell culture can create pancreatic tumor models. This model may have serious effects on cancer research.  Discuss
Genomic landscape of osteosarcomas reveals why immunotherapy may not be effective
Immune profiling of osteosarcoma has revealed why immune checkpoint inhibitors might not be an effective treatment option for patients with this rare type of cancer, according to new research published online February 21 in Nature Communications.  Discuss
Artificial intelligence helps researchers find new antibiotics
To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find new potential antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing.  Discuss
Scientists see through human organs for the 1st time
For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.  Discuss
Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes.  Discuss
Math models improve the effectiveness of immunotherapy
Scientists working at the intersection of math and medicine propose new strategies based on mathematical modeling and known molecular mechanisms to improve the efficacy of lifesaving immunotherapies for cancerous tumors. The work was published on February 3 in the Proceedings of the National Academy of Sciences.  Discuss
Brain's immune system blocks blood immune cells from healing spinal injuries
Molecular and computational analysis of immune responses in the central nervous system reveals that the brain's immune system may prevent blood immune cells from entering a lesion site after injury. The research, published online in Science Advances on January 15, may offer new avenues to treat certain neurological diseases such as multiple sclerosis, Alzheimer's disease, and spinal cord injury.  Discuss
Scientists in the Lab: Featuring Rajan Chaudhari
We are thrilled to introduce our next laboratory scientist this month, who works at the intersection of chemistry, drug development, and data science. Rajan Chaudhari, PhD, is a postdoctoral fellow at the University of Texas MD Anderson Cancer Center in Houston.  Discuss
Together, machine learning and tumor DNA provide new tools for colorectal cancer patients
Researchers utilize a new machine learning platform to identify patients with colorectal cancers and predict their disease severity and survival. The study, published in Science Translational Medicine on January 1, involves samples from over a thousand patients.  Discuss
Precision medicine and molecular understanding of illness
The current era of scientific research is seen by many as a golden age of discovery in genetics, due to rapid progress in numerous areas of science and technology. While healthcare and the pharmaceutical industry traditionally have directed their attention to symptoms rather than underlying causes, the new advances are creating opportunities to better exploit a rapidly expanding mechanistic understanding of disease. The challenges are significant and complex, and the current models of discovery and translation do not provide an obvious path toward an economically sustainable way to integrate data-intensive biology with medicine.  Discuss
Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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