Mice deficient in DCIR are resilient against colitis, colonic tumor growth

By The Science Advisory Board staff writers

August 2, 2022 -- Using mice models, researchers from Japan and China have shown that dendritic cell immunoreceptor (DCIR) protein deficiency is resistant to colonic tumors induced by dextran sodium sulfate (DSS) and azoxymethane (AOM), while identifying an antibody that reduces colitis severity and colonic tumor growth.

Their study, published online August 2 in the journal Cell Reports, highlights the potential of DCIR as a therapeutic target. Although previous studies have suggested that DCIR negatively regulates both innate and acquired immune responses and that blocking it could potentially boost immunity against colon tumors, its role in intestinal immunity has remained unclear.

In the study, mice were fed with drinking water containing DSS, a synthetic sulfated polysaccharide, and AOM, a neurotoxic chemical, to induce colon tumors similar to that observed in humans with inflammatory bowel disease (IBD).

Researchers found that mice lacking DCIR showed reduced colitis severity and colorectal tumor growth induced by AOM-DSS. Moreover, the DCIR-deficient mice showed lower body weight loss as well as reduced proinflammatory cell infiltration in the colon.

"Our findings point to the fact that intestinal carcinogenesis and inflammation are facilitated by DCIR signaling, which points to the possibility that blocking DCIR might prevent ulcerative colitis and colon cancer," Yoichiro Iwakura, professor at the Tokyo University of Science, said in a statement. "Our results suggest that therapeutics targeting DCIR and its ligands could be used to effectively treat autoimmune diseases, IBD, and cancer, which have been traditionally difficult to treat."

Colonic gene mapping provides insights into intestinal diseases
Researchers have used spatial transcriptomics to uncover an unprecedented view of the molecular regionalization of the murine colon. This research, published...
Athos, Cleveland Clinic to partner on IBD research
Athos Therapeutics and the Cleveland Clinic have agreed to collaborate on inflammatory bowel disease (IBD) research. The agreement will advance the use...
New intestine chips promote precision in preclinical models
A new intestine-on-a-chip platform enables researchers to model host-microbiome relationships to gain new insights into the mechanisms of infectious disease...

Copyright © 2022 scienceboard.net


Conferences
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter