B cells hinder intestinal healing, offer potential IBD drug target

By The Science Advisory Board staff writers

December 5, 2022 -- New research reveals that B cells, white blood cells that are critical to the proper functioning of the immune system, greatly increase after bowel damage and prevent the tissue from healing. The findings have implications for the treatment of inflammatory bowel disease (IBD).

Researchers at Karolinska Institutet in Sweden found that the B cell population increases sharply in the colon during the healing of colonic lesions, and these cells mainly accumulate in areas where the damage is severe (Immunity, December 2, 2022). This prevents the interaction between stromal and epithelial cells, which is needed for the tissue to heal.

Using an experimental model of colitis and tissue from patients with ulcerative colitis, they analyzed cell populations. Mice lacking B cells recovered much more quickly after bowel damage than regular mice in their experiments.

Going forward, the researchers will test whether depleting B cells at specific times will be effective with IBD, and if the increase in these cell populations has a long-term benefit.

"There are already approved drugs that affect the B cell response and that are used for other diseases," Gustavo Monasterio, PhD, a postdoc in Eduardo Villablanca's Lab at Karolinska Institutet, said in a statement. "We now want to test if depleting B cells at specific time windows could also work with IBD. We also need to find out if the accumulation of B cells can have a long-term beneficial effect, such as by changing the composition of bacteria in the gastrointestinal tract."

Study finds certain lymphoid cells not superfluous, offers insight into inflammatory diseases
A new study reveals group 2 innate lymphoid cells are not redundant and in fact are essential for protecting the skin, gastrointestinal tract, airways,...
Pain-sensing neurons protect against gut inflammation in mice
Weill Cornell Medicine researchers discovered that pain-sensing neurons protect the gut from inflammation and associated tissue damage by regulating the...
Researchers investigate botanical compounds’ role in reducing intestinal inflammation
Texas A&M University researchers set out to investigate the role of botanical compounds, including dietary phenols, in reducing intestinal inflammation...
Researchers find reactive oxygen species key to inflammation prevention; implications for IBD
Mount Sinai researchers have demonstrated the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during...
Small intestinal organoids optimized to include previously absent Paneth cells
Researchers at the Hubrecht Institute have improved human small intestinal organoids with mature Paneth cells that were not present in previous miniature...

Copyright © 2022 scienceboard.net

Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter