Obsidian, MD Anderson partner on solid tumor cell therapy

By The Science Advisory Board staff writers

November 18, 2020 -- Obsidian Therapeutics and the University of Texas MD Anderson Cancer Center have entered a multiyear strategic collaboration for the research and development of novel engineered tumor infiltrating lymphocytes (TILs) for the treatment of solid tumors.

The agreement will merge Obsidian's cytoDrive technology platform with MD Anderson's experience in TIL cell therapies within its Therapeutics Discovery division. The collaboration will focus on developing TILs armored with regulated membrane-bound interleukin 15 (cytoTIL). The therapy will potentially enhance anti-tumor efficacy and reduce tumor burden in patients suffering from various solid tumors.

The cytoTIL therapy will be engineered using Obsidian's cytoDrive platform, which precisely and reversibly controls protein expression and activity using approved orally bioavailable drugs. By leveraging regulated membrane-bound interleukin-15 (IL-15) to drive antigen-independent expansion of T cells and transactivation of natural killer cells, cytoTIL therapy is anticipated to improve patient response to TIL treatment and expand patient eligibility.

MD Anderson's Biologics Development platform includes an experienced team focused on pioneering biologic therapeutics, such as antibodies and cell therapies. The group is housed in a 60,000-sq-ft good manufacturing practice (GMP) cell therapy manufacturing facility.

Focus Fund, MD Anderson support investigational cancer therapies
The Focus Fund and the University of Texas MD Anderson Cancer Center have teamed up to launch Cancer Focus Fund, an investment fund aimed at supporting...
Bristol Myers Squibb licenses cell therapy candidate from Obsidian
Bristol Myers Squibb has exercised an option to an exclusive worldwide license to a cell therapy candidate based on Obsidian Therapeutics' cytoDrive technology.
MD Anderson, Xencor partner on XmAb candidates
The University of Texas MD Anderson Cancer Center and Xencor have entered a strategic collaboration to study investigational treatments for cancers. Together,...
CNS Pharma partners with MD Anderson
Cancer biopharmaceutical company CNS Pharmaceuticals has entered into a sponsored research agreement with the University of Texas MD Anderson Cancer Center...

Copyright © 2020 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Conferences
Festival of Genomics & Biodata
January 28-29, 2021
London, Greater London United Kingdom
Lab of the Future USA
May 11-12, 2021
Boston, Massachusetts United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter