Flagship Pioneering unveils eRNA platform from Laronde

By The Science Advisory Board staff writers

May 10, 2021 -- Flagship Pioneering unveiled its Laronde platform for the development of endless RNA (eRNA), a novel, engineered form of RNA that can be programmed to express therapeutic proteins inside the body. The company has initially committed $50 million to support the development of the platform and initial pipeline medicines.

The eRNA technology was created at Flagship Labs by Avak Kahvejian, PhD, a Flagship Pioneering general partner and CEO of Laronde, a company that was developed within Flagship Labs.

In 2017, the Laronde team began exploring the therapeutic potential of long noncoding RNA within mammalian cells, which led to the invention of eRNA. These closed-loop RNA constructs are recognized by the innate immune system or exonuclease enzymes and are modular and programmable. The eRNA "protein-coding cassettes" can be switched to make different peptides, enzymes, antibodies, channels, and receptors, both inside and outside of cells.

Laronde plans to build a modular and scalable eRNA manufacturing facility to accommodate the clinical and commercial manufacture of up to 100 products and drug programs in the next 10 years. The company expects to hire more than 200 people over the next two years to support the advancement of its programs and platform.

Repertoire Immune Medicines secures $189M
Repertoire Immune Medicines has completed a round of financing, raising $189 million to further expand its Decode discovery platform, accelerate...
Tessera closes $230M in series B round for gene writing tech
Tessera Therapeutics has raised over $230 million in series B financing to advance its gene writing technology, capable of writing therapeutic instructions...
New AI-based company targets discovery of new protein-based therapeutics
Flagship Pioneering has launched Generate Biomedicines, a new company that will use its machine learning-powered platform for the rapid discovery of new...
Tessera introduces new genome engineering strategy
Flagship Pioneering, a life science venture capital firm, has introduced Tessera Therapeutics -- a new biotechnology company that will use its Gene Writing...

Copyright © 2021 scienceboard.net


Conferences
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter