Buffer exchange is a common step in biologics preparation workflows. Big Tuna automates buffer exchange to formulate, concentrate, and clean up proteins or gene therapy vectors like AAVs, LNPs, and viruslike particles (VLPs).

AAVs are produced at low concentrations and need to be concentrated up for characterization processes, and LNPs are made in the presence of ethanol and need to be cleared quickly for stabilization prior to dosing.

Using Big Tuna's new high molecular weight cutoff plates, concentration application, and tunable pressure settings, AAVs and LNPs can concentrated at precise specifications required by the user.

Unchained Labs launches new gene therapy tool
Unchained Labs has launched a new gene therapy quantification application on Stunner, its gene therapy platform.