Genomics
Genetically engineered probiotics successfully deliver immunotherapies
A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine.  Discuss
Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes.  Discuss
CRISPR proteins developed for use in molecular diagnostics
New CRISPR technology is being developed as a molecular diagnostic tool with the capability of detecting unique disease biomarkers. Eventually, these at-home tests will allow patients to conduct at-home diagnostic tests quickly.  Discuss
Control of molecular 'doormen' in fat cells offers potential new obesity treatment
New treatment options for obesity could emerge from a study published in Nature Communications on January 10. Researchers from Yale University School of Medicine utilized cellular and molecular approaches to identify pathways to restore the healthy balance of fat cells.  Discuss
Nanoparticles direct 'suicide genes' to treat brain tumors in children
Researchers from Johns Hopkins University report a bioengineered nanoparticle that successfully delivers a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. Details of the nanoparticle treatment were published in the January 2020 edition of Nanomedicine: Nanotechnology, Biology and Medicine.  Discuss
Scientists validate large-scale CRISPR-Cas9 screens for cancer models
Researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard, published results of a study in Nature Communications on December 20, which compares consistency among the two largest genetic screen databases of cancer cells lines. The combined data set will help speed the discovery and development of new cancer therapies.  Discuss
Cryo-EM microscopy tool gets an atomic resolution look at "upgraded" CRISPR system
Researchers from Columbia University capture de novo images that reveal unexpected presence transposition proteins that are essential for interactions of CRISPR-like cascade complex. The study was published in Nature on December 18.  Discuss
New CRISPR system efficiently battles antibiotic resistance
Researchers from the University of California San Diego have developed a brand new CRISPR-based gene-drive system that dramatically increases the efficiency of inactivation of genes responsible for antibiotic resistance. The new system is detailed on December 16 in Nature Communications.  Discuss
In vitro CRISPR system allows scientists to detect broad outcomes
As CRISPR technology advances, it is crucial to identify all unintended and potentially harmful changes introduced by gene-editing processes. A new study published in Communications Biology introduces a new system that details broad spectrum outcomes of gene-editing reactions in an unbiased fashion.  Discuss
Modified CRISPR system aims to improve therapies for HIV, sickle cell disease
Researchers from City of Hope have improved the CRISPR-Cas9 system through novel sequence changes to the trans-activating RNA (tracrRNA). The improved tool could help to fast track new therapies for HIV, sickle cell disease and other immune conditions. The results were published in Scientific Reports on November 6.  Discuss
Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
General Discussion
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