Drug Discovery & Development
Large-scale study finds genetic variant responsible for detrimental immune response to common anti-inflammatory drugs
Researchers in the UK seek to understand why commonly used medication fails to treat Chron's disease by identifying a new genetic marker. The research published in Gastroenterology on October 7, identified a genetic variation that decreases the efficiency of anti-tumor necrosis factor (anti-TNF) drugs.
Repurposed drug shows potential to slow neurodegeneration in Parkinson's disease patients
Collaborative research from the University of Iowa and researchers in China and Spain, show evidence that a current drug used to treat prostate cancer may improve Parkinson's disease (PD) symptoms by slow neurodegeneration. The results from experimental models and clinical database analysis were published on September 16, in the Journal of Clinical Investigation.  Discuss
Germline genetic testing in breast cancer patients may lead to increased therapy options
Genetic testing for metastatic breast cancer patients may play a key role in identifying additional patients with increased risk and their response to targeted therapies.  Discuss
Top scientists ousted – potential impacts on mistrust of scientists in the US
Novartis dismissed the top two scientists at its gene therapy division shortly after CEO, Vas Narasimhan, learned of internal data falsification. This controversy comes at a time of high public trust in science and threatens to break that trust with scandals and safety concerns.  Discuss
The Parkinson’s Foundation launches large-scale genetic study, aiming to improve patient care and speed clinical trials
More than 10 million people worldwide are currently living with Parkinson’s disease (PD), a neurodegenerative disorder that impacts the dopamine-producing neurons in the brain. Scientists do not know exactly what causes PD, but they believe it is a combination of genetic and environmental factors. Nearly 10% to 15% of all PD cases are caused by genetic mutations. A new study aims to understand how the disease develops and how it can be treated or cured. This study, PD GENEration: Mapping the Future of Parkinson’s Disease is currently being conducted by the Parkinson’s Foundation.  Discuss
New immunotherapy moves further into clinical testing with promising results
Success in international clinical trials leads to U.S. based research organizations beginning phase I/II clinical trials. If this form of immunotherapy is successful and deemed safe, then it could save the lives of liver cancer patients across the world.  Discuss
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Conferences
11th Annual PEGS Europe
November 18-22
Lisbon Portugal
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
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