Cell Biology
Machine learning helps identify antimicrobial-resistant bacteria
A new graphical user interface-driven, machine learning-based approach has successfully identified antimicrobial resistance genes for gram-positive and -negative bacteria. This work, presented in Scientific Reports on July 3, may make it easier to identify deadly antimicrobial-resistant bacteria.  Discuss
Scientists urge that surveillance of a new SARS-CoV-2 variant is necessary
A SARS-CoV-2 variant carrying an amino acid change, D614G, in the spike protein has become the predominant form of the virus in the current global pandemic. A recent publication in Cell advocated for viral surveillance to aid in the development of immunological interventions.  Discuss
FDA issues guidance on COVID-19 vaccine licensure
The U.S. Food and Drug Administration (FDA) has provided new regulatory guidance for developers of vaccines for COVID-19. The guidance lays out the agency's current recommendations regarding the data needed to facilitate clinical development and licensure of vaccines to prevent COVID-19.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
DNA 'origami' informs coronavirus vaccine design
Strategically folded DNA arranged to mimic viral antigens -- known as DNA "origami" -- may produce strong immune responses, according to a June 29 report in Nature Nanotechnology. Researchers are now working on adapting this approach for the development of a vaccine against SARS-CoV-2.  Discuss
Getting to the heart of SARS-CoV-2 protease; a main drug target
X-ray crystallography performed at room temperature of the main protease of SARS-CoV-2 may be more physiologically relevant than standard low-temperature x-ray structures, according to a June 24 report in Nature Communications.  Discuss
Computer tools shorten development time for SARS-CoV-2 drugs
Computer-based tools are helping researchers find potentially promising candidates for vaccines and treatments for SARS-CoV-2 -- and much more quickly than traditional approaches. Many of these software tools are described in an article published June 24 in Science Advances.  Discuss
Researchers discuss progress toward personalized cancer vaccines
Highly targeted and adaptable platforms allow researchers to develop cancer vaccines for a multitude of different cancer types and even create personalized vaccines for individual cancer patients. Researchers from BioNTech and the Wistar Institute shared exciting developments in cancer vaccines in a methods workshop during the American Association for Cancer Research 2020 virtual annual meeting II.  Discuss
Childhood vaccines may help protect against COVID-19 mortality
Could live vaccines for viruses such as measles, mumps, and rubella (MMR) also provide protection against COVID-19? That intriguing prospect is the subject of a recently published commentary in mBio.  Discuss
Some viruses may steal host genes to form beneficial hybrid proteins
Certain types of RNA viruses may be capable of using host RNA to expand their own genetic repertoire, according to a new study published in Cell on June 18. This mechanism may enable viruses to overcome the limitations of small genomes and more effectively infect host cells.  Discuss
Conferences
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
BioProcess International
September 21-24
Eastern Standard Time Zone (EST), Massachusetts United States
General Discussion
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Childhood vaccines may help protect against COVID-19 mortality
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