Cell Biology
New CRISPR Cas13 system offers powerful antiviral protection
A first-of-its-kind study conducted by researchers at the Broad Institute of MIT and Harvard demonstrates that Cas13, a class 2 CRISPR system, can be used as an antiviral in cultured human cells. The research, published in Molecular Cell on October 10, suggests that the RNA-cutting enzyme can be programmed to detect and destroy RNA-based viruses.  Discuss
DNA Metabarcoding used to analyze human diet
A collaborative study from US researchers demonstrates that DNA metabarcoding has promise for characterization of human diets. The research, which was published in mSystems on October 8, provides evidence that DNA sequencing-based approaches can be successfully applied to human samples.  Discuss
Protein receptors imaged by cryoelectron microscopy help scientists understand inflammation
Researchers at Oregon Health & Science University used cryoelectron microscopy (cryo-EM) to observe protein structure and function at a molecular level. This discovery, published in Cell on October 3 describes the structure of P2X receptor, a cellular membrane protein receptor, and provides insight into how the cation channel functions.  Discuss
Driven by nanotech and other micro technologies electron microscopy market continues to grow
According to a new report from Strategic Directions International (SDI), the total market for electron microscopy instrumentation was in excess of $2.5 billion in 2018 and is expected to reach nearly $3.4 billion by 2023.  Discuss
Forward-oriented gene therapy improves treatment for sickle cell disease
Researchers at the National Institutes of Health (NIH) have developed a new and improved viral vector that is up to 10 times more efficient at incorporating corrective genes into bone marrow stem cells than conventional treatments. The work was published in Nature Communications on October 2, and was supported by the National Heart Lung, and Blood Institute (NHLBI) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the NIH.  Discuss
Bacteria use 'poisoned arrowheads' to defeat competition, similar to antibiotics
According to a new study published in Cell Reports on October 1, bacteria use weapons to vanquish their competitors. Researchers at Imperial College London have uncovered a novel weapon that bacteria employ which has a similar mechanism of action as common antibiotics.  Discuss
Understanding bacterial motility using cryogenic electron microscopy
A new finding reported in Nature Structural & Molecular Biology on October 1 shows how bacterial transmit motion from an inner motor to an outer tail through a flexible joint in the flagellum. This hook helps researchers understand how bacteria move and allows them to improve therapies against bacterial infections.  Discuss
Viral geometry mystery solved, or at least they have a theory
A new theory, published in Nature Communications on September 27, accurately predicts the positions of proteins within icosahedral (twenty-sided) protein containers of viruses. Researchers at the University of York in the UK and San Diego State University in the US state that this discovery revolutionizes scientific understanding of how viruses form, evolve and infect hosts.
Form-switching bacteria may cause antibiotic resistance
For the first time, scientists have confirmed that bacteria can change forms to avoid being targeted by antibiotics in the human body. Researchers from Newcastle University used state-of-the-art technology to identify bacteria with this unique characteristic. They show, in a study published in Nature Communications on September 26, that these bacteria can survive without a cell wall, potentially leading to antibiotic resistance.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
Conferences
Antibody Engineering & Therapeutics
December 9-13
San Diego, California United States
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29, 2020
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30, 2020
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30, 2020
London, Greater London United Kingdom
Medlab Middle East
February 3-6, 2020
Dubai, Dubai United Arab Emirates
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