XBiotech's monoclonal antibody cocktail shows promise for COVID-19, influenza

By The Science Advisory Board staff writers

November 19, 2020 -- XBiotech has released data for its Fluvid therapy to treat infections of influenza and COVID-19.

The "true human" antibodies (antibodies derived without modification from humans who possess natural immunity to certain diseases) targeting SARS-CoV-2 were found to effectively neutralize the virus at concentrations around four times better than other antibodies under consideration from the U.S. Food and Drug Administration for emergency use authorization. The company's therapeutic cocktail also targets influenza. The unique combination of targeting both SARS-CoV-2 and all known strains of influenza could provide the company with a uniquely effective therapy for treating complex infections from one or more viruses.

The Fluvid candidate therapy was developed by XBiotech by incorporating influenza true human antibodies that have been evaluated for their ability to target all known strains of influenza viruses with true human COVID-19 antibodies that are derived from patients who recovered rapidly with potent neutralizing antibodies against the virus.

The company's Fluvid candidate targets seasonal H1N1 and H3N2 strains; pandemic strains H1N1, H2N2, H3N2; avian influenza strains H5N1, H5N2 and H7N9; and even H9N2 and H10N8 (found in poultry).

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