Autologous cell therapy has its limitations, risks

May 16, 2022 -- Cell-based therapies generated using a patient's own cells, called autologous cell therapy, have their own inherent risks and limitations, contends Roman Vincent, senior global director of strategic marketing at MaxCyte.

"When you are treating the cells, you have pretty much the life of a patient in your hands," Vincent told at the International Society for Cell & Gene Therapy (ISCT) 2022 annual meeting in San Francisco. "It's so precious. You cannot have a problem."

However, cells delivered to a manufacturing facility and then back to a clinic are prone to damage, loss, and risk of cross contamination. In addition, cells can originate from unhealthy patients that are exposed to prior chemotherapeutic agents.

While automation and standardization are the goal, Vincent makes the case that the quality of the cells vary depending on the health and age of the patients as well as the previous treatments they have received. "There's so much more that we need to understand at the biological level. To try to standardize today, the major problem is also that it's so complex. There are so many opportunities for mishandling," he said.

Watch the video below to learn more.

What's needed for cell and gene therapies to become the new standard of care?
Cell and gene therapies (CGTs) have the potential to be the new standard of care. Delara Motlagh, PhD, general manager at Terumo Blood and Cell Technologies,...
CGT ecosystem is only way to accelerate development for more patients: Autolomous COO
Digital solutions provider Autolomous specializes in building solutions for the cell and gene therapy (CGT) industry with an emphasis on collaborative...
Automation, standardization hold potential for overcoming CGT manufacturing challenges
Challenges in cell and gene therapy (CGT) manufacturing can be overcome by fully automating and standardizing the process, contends David Smith, vice...
Galipeau to replace Levine as ISCT president
Dr. Jacques Galipeau, associate dean for therapeutics development at the University of Wisconsin-Madison, is set to replace Bruce Levine, PhD, professor...
ISCT22 co-chair recounts how far CGT industry has come
Advancements in the field of cell and gene therapies (CGTs) have made them a therapeutic reality, according to Bambi Grilley, director of clinical research...
ISCT22: RoosterBio, ShiftBio partner to harness the power of MSCs, exosomes
RoosterBio, a supplier of human mesenchymal stem/stromal cells (MSCs), recently announced a strategic partnership with ShiftBio, a South Korean company...
ISCT22: Scale up of cell therapy manufacturing is a significant, but addressable challenge
The cell therapy industry is facing a significant but addressable challenge when it comes to scaling up manufacturing, according to Bob Newman, PhD, chief...
ISCT22: BroadOak’s Poltilove remains bullish on CGT market despite downturn
Bryan Poltilove, partner at BroadOak Capital Partners, spoke with at the International Society for Cell & Gene Therapy (ISCT)...
ISCT22: Orgenesis looks to simplify, lower costs of providing CGT therapies
Personalized cell and gene therapies (CGTs) offer the potential to address the most challenging diseases, Vered Caplan, CEO of biotech company Orgenesis,...
ISCT22: Children's National sees improved cell therapy potency, quicker patient delivery
Children's National Hospital in Washington, DC, is seeing improvements in the potency of existing cell therapies and a reduction in the time it takes...
ISCT22: Antion Biosciences CEO highlights new way of approaching allogeneic cell creation
Dr. Sven Kili, CEO of Antion Biosciences, contends the Swiss company’s microRNA (miRNA) technology (miCAR platform) is a new way of approaching allogeneic...
ISCT president calls for cell and gene therapy education, training amid ‘talent shortage’
This week in San Francisco, industry, investors, physicians, patients, and regulators convened at the International Society for Cell & Gene Therapy (ISCT)...
ISCT working group weighs in on expanded access to CGT
Patricia Zettler, JD, associate professor of law at The Ohio State University, and chair of the International Society for Cell & Gene Therapy (ISCT) Expanded...
ISCT22: Cell therapy has potential to address unmet medical needs in orthopedics
Miguel Forte, CEO of Bone Therapeutics, and president-elect of the International Society for Cell & Gene Therapy (ISCT), spoke with
ISCT22: Tackling the ethical issues around cell and gene therapy
Unproven and unethical cell and gene therapies are a growing problem worldwide, according to Laertis Ikonomou, PhD, of the Department of Oral Biology...

Copyright © 2022

Microscopy and Microanalysis Meeting
July 31 - August 4
Portland, Oregon United States
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter