Study shows breast cancer metastases form more efficiently during sleep

By The Science Advisory Board staff writers

June 22, 2022 -- A new study by researchers at ETH Zurich, the University Hospital Basel, and the University of Basel shows that breast cancer metastases form more efficiently while patients are sleeping.

While cancer research has paid little attention to the question of when tumors shed metastatic cells, the researchers discovered that circulating cancer cells that form metastases arise during sleep.

The study, which included 30 female cancer patients and mouse models, found that the tumor generates more circulating cells when the organism is asleep. In addition, the study showed that cells that leave the tumor at night also divide more quickly and therefore have a higher potential to form metastases, compared to circulating cells that leave the tumor during the day.

"Our research shows that the escape of circulating cancer cells from the original tumor is controlled by hormones such as melatonin, which determine our rhythms of day and night," said Zoi Diamantopoulou, the study's lead author and a postdoctoral researcher at ETH Zurich.

Copyright © 2022

Microscopy and Microanalysis Meeting
July 31 - August 4
Portland, Oregon United States
Glasgow International Health Festival
August 24-27
Glasgow, Glasgow City United Kingdom
Pharma Competitive Intelligence Conference and Exhibition
September 21-22
Newark, New Jersey United States
BioProcess International (BPI) Conference
September 27-30
Boston, Massachusetts United States
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter