PerkinElmer debuts test kit to expand GPCR therapies

By The Science Advisory Board staff writers

January 27, 2021 -- PerkinElmer has debuted new assay kits to help further G protein-coupled receptor (GPCR) drug discovery.

The kits enable researchers to use preferred cell models of their choices, including the homogeneous time resolved fluorescence (HTRF) guanosine-5'-triphosphate (GTP) Gi binding kit, the industry's first time-resolved fluorescence energy transfer (TR-FRET)-based assay for GTP binding, as well as the B-arr2 recruitment kit and HTRF total kits for B-Arrestin 1, B-Arrestin 2 and AP2.

Using these tests will help scientists understand the role GPCRs play in disease by studying the interaction, expression, and potential modulation of intracellular proteins involved in their signaling mechanisms.

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