Istari wins orphan drug designation for melanoma therapy

By The Science Advisory Board staff writers

January 11, 2021 -- The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to Istari Oncology for its PVSRIPO technology as a treatment for stage IIB-IV melanoma.

PVSRIPO is a viral immunotherapy based on the Sabin type 1 polio vaccine. It activates the immune system to promote an antitumor response and prevent cancer's return and showed promising clinical results in a phase I clinical study.

The orphan drug designation is the first for Istari in 2021. Istari intends to continue developing PVSRIPO for multiple indications, and the company anticipates hitting more milestones later in the year.

Istari is currently recruiting patients for Luminos-102, a phase II randomized clinical trial to study the use of a PVSRIPO intratumoral injection in patients with advanced, unresectable melanoma who have failed anti-programmed cell death 1 (PD-1) therapy. The company plans to dose its first patient in the trial in the first quarter of this year.

New immunotherapy piggybacks off polio vaccine to treat cancer
As if we needed another reason to get vaccinated, researchers have developed a technology that leverages the polio vaccine to help treat cancer for those...
Are people in your state getting vaccinated?
Support for a COVID-19 vaccine continues to wane even as companies report being closer to bringing one to the public. This may not be surprising, considering...
Researchers discuss progress toward personalized cancer vaccines
Highly targeted and adaptable platforms allow researchers to develop cancer vaccines for a multitude of different cancer types and even create personalized...
Next-generation sequencing reveals inherited mutations in young cancer patients
Researchers advocated for increased genomic surveillance in younger adult cancer patients with tumors that typically strike later in life, in a study...
Innovations in synthetic chemistry help identify new cancer therapies
The pathway to discovering and developing cancer therapies is not always linear, but well-designed models incorporating smart chemical innovations can...

Copyright © 2021

Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter