TreeFrog, Invetech partner on automated single-use stem cell encapsulation

By The Science Advisory Board staff writers

October 8, 2020 -- TreeFrog Therapeutics and Invetech have entered a strategic partnership to develop a good manufacturing practices (GMP)-compliant device for high-throughput stem cell encapsulation by the end of 2022.

The companies have been collaborating since 2019 to turn the TreeFrog research and development (R&D) encapsulation set-up into an automated single-use device for industrial bioproduction. A beta encapsulation system designed by Invetech achieves a throughput of 1,000 stem cell capsules per second.

TreeFrog Therapeutics
TreeFrog Therapeutics's beta encapsulation system. Image courtesy of TreeFrog.

Stem cell encapsulation protects cells against hydrodynamic damages, which is helpful in large-scale bioproduction. Encapsulation can also recapitulate a biomimetic stem cell niche to promote fast growth and accurate chromosome segregation, according to the firms. The new technology has the potential to reduce manufacturing costs by 10-fold while improving batch size, yields, and genomic quality.

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