Bioimaging & Microscopy
Atomic structures revealed by cryo-EM may lead to new antiviral drugs
Using cryo-electron microscopy (cryo-EM), researchers found unique structures of paramyxoviruses that can lead to a better understanding of viral replication, which in turn can be leveraged to develop improved antiviral drugs. The details were published in the Proceedings of the National Academy of Sciences on February 17.  Discuss
Microscopy with fluorescent tags gives high-def view of diabetes-related proteins
Leveraging the power of new imaging techniques, scientists are using unique fluorescent tags in combination with superresolution microscopy to gain novel insights into a receptor that plays a key role in controlling blood sugar levels. These insights will open the door to improved treatment options for type 2 diabetes.  Discuss
Correlative microscopy provides view of subcellular components
As technology improves and knowledge of molecular biology increases, there is a need to view and analyze the complex organization of cells. That's become possible thanks to a new methodology based on correlative microscopy, which uses a combination of fluorescence and electron microscopy to seamlessly zoom in and out of a sample. The protocol was described in Science on January 17.  Discuss
Novel mitochondrial phenomenon helps explains early neurodegeneration
Northwestern University Feinberg School of Medicine scientists discovered a novel pathway that leads to neurodegeneration in amyotrophic lateral sclerosis (ALS). The study was published in Frontiers in Cellular Neuroscience on November 7. The pathway could explain the development of early stages of neurodegeneration which affects voluntary muscle movement such as walking and talking.  Discuss
Cutting edge microscopy technique leads to new insights in cancer
New research published in the October 31 edition of Science debuts a new technique for creating high-resolution visual maps of the chromatin structure remodeling (RSC) complex to further understand its role in healthy and cancer cells. This research was led by Bradley Cairn, PhD, cancer researcher at Huntsman Cancer Institute and professor and chair of oncological sciences at the University of Utah.  Discuss
New bio-imaging techniques help scientists understand the early stages of Parkinson's disease
Scientists observed, for the first time ever, how variants of Parkinson's disease-associated protein alpha-synuclein change over time and identify the initial stages of protein aggregates. A new study published in Nature Communications on October 10 helps to clarify the why treatment challenges associated with Parkinson's disease (PD), when does it begin.  Discuss
Protein receptors imaged by cryoelectron microscopy help scientists understand inflammation
Researchers at Oregon Health & Science University used cryoelectron microscopy (cryo-EM) to observe protein structure and function at a molecular level. This discovery, published in Cell on October 3 describes the structure of P2X receptor, a cellular membrane protein receptor, and provides insight into how the cation channel functions.  Discuss
Understanding bacterial motility using cryogenic electron microscopy
A new finding reported in Nature Structural & Molecular Biology on October 1 shows how bacterial transmit motion from an inner motor to an outer tail through a flexible joint in the flagellum. This hook helps researchers understand how bacteria move and allows them to improve therapies against bacterial infections.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
Novel "death star" nanoparticle discovered for potential use in targeted therapies
A novel nanoparticle has been reported by researchers at San Diego State University with the potential to serve as a delivery system for therapeutics. The research published on September 17 in eLife describes how Metamorphosis Associated Contractile structures (MACs) trigger metamorphosis in tubeworms. Moreover, they identify a novel protein (with syringe-like structures, nicknamed Death Star for the effect it has) responsible for the activation of metamorphosis.  Discuss
Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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