Biochemistry
Artificial intelligence helps researchers find new antibiotics
To address antibiotic resistance, researchers have developed a machine-learning approach that can search millions of known chemicals to find potential new antimicrobial compounds. This research, published in Cell on February 20, uncovered several promising antibiotic candidates that will move into clinical testing.  Discuss
Breakthrough in coronavirus research provides map for vaccines
Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Genetically engineered probiotics successfully deliver immunotherapies
A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine.  Discuss
3D model of human intestines helps simulate leaky gut condition
Researchers are using 3D models of human intestines to simulate leaky gut conditions -- in which microbes and molecules seep out of the intestines, eliciting an immune response. The research, published in Life Science Alliance on February 10, will help identify biomarkers for leaky gut for improved diagnostics and treatment development.  Discuss
Brain's immune system blocks blood immune cells from healing spinal injuries
Molecular and computational analysis of immune responses in the central nervous system reveals that the brain's immune system may prevent blood immune cells from entering a lesion site after injury. The research, published online in Science Advances on January 15, may offer new avenues to treat certain neurological diseases such as multiple sclerosis, Alzheimer's disease, and spinal cord injury.  Discuss
Microscopy with fluorescent tags gives high-def view of diabetes-related proteins
Leveraging the power of new imaging techniques, scientists are using unique fluorescent tags in combination with superresolution microscopy to gain novel insights into a receptor that plays a key role in controlling blood sugar levels. These insights will open the door to improved treatment options for type 2 diabetes.  Discuss
Yeast metabolism may offer lessons on starving cancer cells
Scientists may have found a new way to starve cancer cells by learning from growth regulation mechanisms employed by yeast. They found that the same metabolic mechanism used by yeast to respond to nutrient shortages is also employed by mammalian cells -- a finding that could lead to new cancer therapies, according to a new study published in Nature Metabolism on January 20.  Discuss
Scientists learn how lactate contributes to cancer formation
Previously considered a waste product of metabolism, lactate may play a crucial role in cancer growth, according to a study published in Frontiers in Oncology on January 14. Researchers from the University of Colorado Anschutz Medical Campus explored how lactate affects transcription of oncogenes in breast cancer cells.  Discuss
Dietary probiotics show potential to reverse Parkinson's symptoms
Roundworms that were fed a commercially available dietary probiotic showed less buildup of proteins that form during the progression of Parkinson's disease in a new study, published in Cell Reports on January 14. The finding provides further evidence of a link between the gut microbiome and brain function.  Discuss
Control of molecular 'doormen' in fat cells offers potential new obesity treatment
New treatment options for obesity could emerge from a study published in Nature Communications on January 10. Researchers from Yale University School of Medicine utilized cellular and molecular approaches to identify pathways to restore the healthy balance of fat cells.  Discuss
Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
General Discussion
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Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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