Biochemistry
Breakthrough in coronavirus research provides map for vaccines
Critical research reveals the 3D atomic-scale map of the spike protein of the 2019 novel coronavirus (2019-nCoV), which is responsible for infecting humans. This breakthrough will aid in the development of vaccines and antiviral drugs to combat the spread of the virus. The research was published in Science on February 19.  Discuss
Scientists see through human organs for the 1st time
For the first time, scientists have made human organs transparent with the use of a new imaging technique called SHANEL, which stands for small-micelle-mediated human organ efficient clearing and labeling. The details were published in Cell on February 13.  Discuss
Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes.  Discuss
3D model of human intestines helps simulate leaky gut condition
Researchers are using 3D models of human intestines to simulate leaky gut conditions -- in which microbes and molecules seep out of the intestines, eliciting an immune response. The research, published in Life Science Alliance on February 10, will help identify biomarkers for leaky gut for improved diagnostics and treatment development.  Discuss
NGS of China coronavirus shows bat origins, intermediate host
Next-generation sequencing (NGS) of 10 genomes of novel coronavirus (2019-nCoV) from nine patients in China demonstrated that the virus is closely related to two coronaviruses that originated in bats, but that an intermediate host may be responsible for the spread to humans, according to a study published in Lancet on January 29, 2020.  Discuss
Nanoparticles eat cardiovascular plaques from the inside out
Scientists have engineered a nanoparticle that eats plaques associated with cardiovascular disease -- from the inside out. This Trojan horse technology could offer a new therapeutic option for the treatment of atherosclerosis, according to a study published in Nature Nanotechnology on January 27.  Discuss
Microscopy with fluorescent tags gives high-def view of diabetes-related proteins
Leveraging the power of new imaging techniques, scientists are using unique fluorescent tags in combination with superresolution microscopy to gain novel insights into a receptor that plays a key role in controlling blood sugar levels. These insights will open the door to improved treatment options for type 2 diabetes.  Discuss
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration.  Discuss
Yeast metabolism may offer lessons on starving cancer cells
Scientists may have found a new way to starve cancer cells by learning from growth regulation mechanisms employed by yeast. They found that the same metabolic mechanism used by yeast to respond to nutrient shortages is also employed by mammalian cells -- a finding that could lead to new cancer therapies, according to a new study published in Nature Metabolism on January 20.  Discuss
Correlative microscopy provides view of subcellular components
As technology improves and knowledge of molecular biology increases, there is a need to view and analyze the complex organization of cells. That's become possible thanks to a new methodology based on correlative microscopy, which uses a combination of fluorescence and electron microscopy to seamlessly zoom in and out of a sample. The protocol was described in Science on January 17.  Discuss
Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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Conferences
2nd Annual BioIT World Conference & Expo West
March 1-4
San Francisco, California United States
BioProcess International US West
March 9-12
Santa Clara United States
Microbiology Society Annual Conference 2020
March 30 - April 3
Edinburgh, Edinburgh, City of United Kingdom
Experimental Biology 2020
April 4
San Diego, California United States
BioProcess International Europe
April 28 - May 1
Amsterdam, Noord-Holland Netherlands
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