Lilly's mAb highly protective against COVID-19 in nursing homes

By The Science Advisory Board staff writers

January 22, 2021 -- Eli Lilly's monoclonal antibody (mAb) LY-CoV555 (bamlanivimab) significantly reduced the risk of contracting COVID-19 among residents and staff of long-term care facilities, the firm said.

The results stem from the firm's phase III Blaze-2 COVID-19 prevention trial, which was conducted in partnership with the U.S. National Institute of Allergy and Infectious Diseases (NIAID). The study enrolled 965 residents and staff at skilled nursing and assisted living facilities across the U.S. Some participants tested negative for SARS-CoV-2 at baseline while others did not. However, all participants were randomized to receive either 4,200 mg of bamlanivimab or a placebo.

After eight weeks of follow-up, researchers found a significantly lower frequency of symptomatic COVID-19 in the bamlanivimab treatment arm versus a placebo. The results suggest that residents randomized to bamlanivimab have up to an 80% lower risk of contracting COVID-19 versus the residents in the same facility randomized to a placebo.

Four deaths were attributed to COVID-19 and occurred in the placebo arm while no deaths were attributed to COVID-19 in the bamlanivimab arm. Over the entire trial, 16 deaths were reported, including deaths not related to COVID-19. All deaths were residents -- 11 in the placebo arm and five in the bamlanivimab arm.

BLAZE-2 is an ongoing open-label trial. The full results of the trial will be presented at a future medical congress and submitted for publication in a peer-reviewed clinical journal, Eli Lilly said.

Top biopharma companies form data exchange nonprofit
Ten of the world's largest biopharmaceutical companies publicly launched a new nonprofit corporation, Accumulus Synergy. The aim is to support interactions...
Lilly, Merus to develop T-cell redirecting bispecific antibodies
Eli Lilly research and development group Loxo Oncology and oncology firm Merus have signed a research collaboration and exclusive license agreement with...
Lilly to acquire Prevail Therapeutics for $1B
Eli Lilly will acquire Prevail Therapeutics for a total consideration of up to $26.50 per share in cash, or an aggregate of approximately $1.04 billion,...
Lilly to provide U.S. with 650K more COVID-19 antibody doses
The U.S. government has purchased an additional 650,000 doses of Eli Lilly's neutralizing antibody, bamlanivimab, for $812.5 million.
FDA issues EUA for Lilly's JAK inhibitor plus remdesivir for COVID-19
The U.S. Food and Drug Administration (FDA) has issued an emergency use authorization (EUA) for the drug baricitinib, a janus kinase (JAK) inhibitor,...

Copyright © 2021 scienceboard.net


Register below for our weekly Letter from the Editor to receive the latest Science news and insights.
Email
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter