Immatics to highlight ACTengine program updates at SITC

By The Science Advisory Board staff writers
November 1, 2021

Immatics plans to offer an update on its ACTengine IMA203 trial at the upcoming Society for Immunotherapy of Cancer (SITC) 2021 annual meeting in Washington, DC, November 12-13.

The company's ACTengine is a next-generation CD8ab T-cell receptor T-cell (TCR-T) approach used to develop T cell-redirecting cancer immunotherapies. The approach uses a patient's own T cells that are genetically engineered to express a novel, proprietary T-cell receptor directed against a defined cancer target. The modified T cells are then reinfused into the patient to attack the tumor, an approach also known as TCR-T.

The update will be delivered by Dr. Martin Wermke of the University Hospital Carl Gustav Carus in Dresden, Germany, in a presentation titled "Safety and Anti-Tumor Activity of TCR-Engineered Autologous, PRAME-Directed T Cells Across Multiple Advanced Solid Cancers at Low Doses," according to Immatics.

A second presentation delivered by the company's director of process development, Mamta Kalra, PhD, will update attendees on the company's next-generation CD8ab TCR-T approach, it said.

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Last Updated ka 11/4/2021 12:54:27 PM