Transcriptomics help visualize diffuse midline glioma
A Dana-Farber-led team used spatial single-cell transcriptomics to visualize diffuse midline glioma cancer cell structure across different age groups and locations. Their study, published December 5 in the journal Nature Genetics, provides insights that may facilitate new treatment approaches for this rare cancer. Read More
Rice University lab receives $3M grant to develop HIV treatment
Researchers from Rice University have been awarded a $3 million grant from the Bill & Melinda Gates Foundation to develop a once-a-year treatment for HIV and other infectious diseases. Read More
Researchers discover ‘QR code’ of GPCR protein couplings
Scientists from cancer research and treatment center City of Hope have identified how the G protein-coupled receptor (GPCR) works, which could further investigations of how the protein’s coupling with other proteins can impact how cells respond to medicines with fewer side effects. Read More
Mutated protein causes Parkinson's, protects against MSA
A single change in the misfolding protein that causes Parkinson's disease can protect against multiple system atrophy (MSA), University of Massachusetts Amherst scientists found. Read More
Opioids could be made safer by targeting sodium pockets: study
Chemically linking fentanyl to the sodium pockets that exist within nerve cell receptors could block the drug's harmful side effects and still reduce pain, according to a new study. Read More
B cells hinder intestinal healing, offer potential IBD drug target
New research reveals that B cells, white blood cells that are critical to the proper functioning of the immune system, greatly increase after bowel damage and prevent the tissue from healing. The findings have implications for the treatment of inflammatory bowel disease (IBD). Read More
Researchers pinpoint gene leading to childhood glaucoma
A genetic mutation in the thrombospondin-1 gene leads to the development of severe childhood glaucoma and the discovery may improve disease screening and personalize treatments, a team of scientists has found. Read More
Vaccines offer long-term protection against severe COVID-19 in monkeys
New research indicates that two-dose experimental SARS-CoV-2 vaccines provide protection against COVID-19-related lung disease in year-old rhesus macaques vaccinated as infants. Read More
CIRM awards $8M for gene therapy research on rare, incurable diseases
The California Institute for Regenerative Medicine (CIRM) has awarded $8 million in grants for two research teams investigating gene therapy for rare and incurable diseases. Read More
New approach facilitates natural products drug discovery
A new approach to natural products drug discovery integrates information from molecular biology, analytical chemistry, and bioinformatics to help address the current challenges of screening these products to identify potential drugs. Read More
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