In a study involving 28 mismatch repair-proficient tumors and 34 mismatch repair-deficient colorectal cancer samples, researchers from the Broad Institute of MIT and Harvard used single-cell transcriptomics, in situ hybridization, and GeoMx DSP to assess the mechanisms governing interactions between colorectal tumor cells and tumor-infiltrating immune cells.

The researchers quantified cellular programs defined by single-cell RNA sequencing and mapped their interactions using the GeoMx Cancer Transcriptome Atlas assay across 135 regions of interest in a subset of tumors with a high number of potentially tumor-reactive T cells. This revealed the spatial transcriptional regulation that organizes immune-malignant cell networks, according to the company.

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