Graphite Bio sees its gene editing tech as step above CRISPR


May 26, 2022 -- While the use of CRISPR is an effective gene editing tool on its own, Dr. Josh Lehrer, CEO of Graphite Bio, contends that the technology doesn’t correct the underlying genetic defect.

CRISPR is the "cut" function and Graphite Bio's technology is the "cut and paste" capability, Lehrer told ScienceBoard.net at the American Society of Gene & Cell Therapy (ASGCT) 2022 annual meeting in Washington, DC.

"We have a slightly different approach where what we're trying to do is use CRISPR essentially as more than a pair of scissors. We're trying to build on CRISPR technology to get to very efficient, reproducible, precise cutting and pasting," Lehrer said.

The targeted approach is designed to precisely replace defective genes at their native chromosomal location, allowing for the production of normal gene expression within the inserted cells. Graphite Bio uses a CRISPR system to leverage a natural repair process of cells called homology-directed repair, without introducing any errors.

Watch the video below to learn more.



Copyright © 2022 scienceboard.net
 

Create an Account

Already have an account? Sign in Here

To access all ScienceBoard content create a free account now:



Email Address:  

First Name:

Last Name:

Learn about ScienceBoard

Get the latest life sciences research and industry news, delivered straight to your inbox, for free.

Why subscribe?

ScienceBoard is uniquely focused on the business of research, addressing the biggest problems that the biomedical industry face. You’ll get breaking news, events coverage, and deep dives into the science that drives innovation, delivered to your inbox daily.

 
I have read and agree to the privacy policy and terms of service and wish to opt-in for ScienceBoard.net.

Email Preferences



Letter from the Editor Please send me twice-weekly roundups of all the latest life research and industry news.
SAB Announcements Please send me the latest announcements from The Science Advisory Board and their partners.
Spotlight Receive notifications about new content, services, or educational resources designed to help you sharpen your skills and grow professionally.