Cellectis, Sanofi partner on UCART clinical trials

By The Science Advisory Board staff writers

May 12, 2021 -- Sanofi has agreed to supply anti-CD52 monoclonal antibody alemtuzumab for use in a lymphodepleting regimen in Cellectis-sponsored universal chimeric antigen receptor T-cell (UCART) trials.

Using alemtuzumab in a lymphodepleting regimen should reduce a patient's host immune cells and improve allogeneic CAR T-cell expansion and persistence. UCART T cells are being evaluated for the treatment of relapsed/refractory acute lymphocytic leukemia and relapsed/refractory acute myeloid leukemia.

The companies agreed to execute a commercial supply of alemtuzumab, although financial details were not disclosed.


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