New AI-based company targets discovery of new protein-based therapeutics

By The Science Advisory Board staff writers

September 10, 2020 -- Flagship Pioneering has launched Generate Biomedicines, a new company that will use its machine learning-powered platform for the rapid discovery of new drugs across a range of modalities, including antibodies, peptides, enzymes, and cytokines, and entirely new protein-based therapeutics.

The company's proprietary Generate Biology platform will learn from known proteins to encode and apply the fundamental principles of how genetic sequences lead to protein structure and function to create novel protein sequences with optimized therapeutic potential, according to the company.

The platform can overcome conventional challenges of protein drug discovery. Using the platform, it will be possible to generate antibodies or bindings to prespecific epitopes on a target and antibodies to membrane targets or multiprotein complexes. The company anticipates the platform can also generate therapies that can agonize targets or control specific signaling, and selectively identify these molecules.

In response to the COVID-19 pandemic, Generate Biomedicines applied the platform to generate therapeutic candidates against SARS-CoV-2 in a matter of weeks. The candidates are being developed in partnership with the Coronavirus Immunotherapy Consortium.

Copyright © 2020

Create an Account

Already have an account? Sign in Here

To access all ScienceBoard content create a free account now:

Email Address:  

First Name:

Last Name:

Learn about ScienceBoard

Get the latest life sciences research and industry news, delivered straight to your inbox, for free.

Why subscribe?

ScienceBoard is uniquely focused on the business of research, addressing the biggest problems that the biomedical industry face. You’ll get breaking news, events coverage, and deep dives into the science that drives innovation, delivered to your inbox daily.

I have read and agree to the privacy policy and terms of service and wish to opt-in for

Email Preferences

Letter from the Editor Please send me twice-weekly roundups of all the latest life research and industry news.
SAB Announcements Please send me the latest announcements from The Science Advisory Board and their partners.
Spotlight Receive notifications about new content, services, or educational resources designed to help you sharpen your skills and grow professionally.