Sanofi to acquire Principia Biopharma for $3.7B

By The Science Advisory Board staff writers

August 17, 2020 -- Sanofi has announced that it plans to acquire Principia Biopharma for $3.7 billion.

Principia's Bruton tyrosine kinase (BTK) inhibitors will boost Sanofi's efforts to build a portfolio of the next generation of treatments for autoimmune diseases, according to the firm. BTK is present in signaling pathways of key innate and adaptative cell types of the immune system. Blocking these proteins can disrupt signaling and stop inflammation and tissue destruction.

The roster includes:

  • BTK inhibitor '168, which is in a phase IIb study in patients with multiple sclerosis.
  • Rilzabrutinib, which is in a phase III program for patients with moderate to severe pemphigus.
  • Prn473 Topical, which is in phase I trials for immune diseases that manifest in the skin.

The programs are designed on Principia's Tailored Covalency platform, which creates reversible covalent and irreversible covalent small molecule inhibitors that are more selective with less off-target effects.

The deal has been approved by both companies' board of directors and is expected to close in the fourth quarter of this year, the two firms said.

Copyright © 2020
To access all The ScienceBoard content create a free account now:

Email Address:  

First Name:

Last Name:

Learn about ScienceBoard

Get the latest life sciences research and industry news, delivered straight to your inbox, for free.

Why subscribe?

ScienceBoard is uniquely focused on the business of research, addressing the biggest problems that the biomedical industry face. You’ll get breaking news, events coverage, and deep dives into the science that drives innovation, delivered to your inbox daily.

Letter from the Editor Please send me twice-weekly roundups of all the latest life research and industry news.
SAB Announcements Please send me the latest announcements from The Science Advisory Board and their partners.
Spotlight Receive notifications about new content, services, or educational resources designed to help you sharpen your skills and grow professionally.
I have read and agree to the privacy policy and terms of service and wish to opt-in for

Already have an account? Sign in here