Precision BioSciences highlights hepatitis B virus drug research

By The Science Advisory Board staff writers

May 19, 2022 -- Precision BioSciences is highlighting new research showing that its gene editing drug candidate targeting the hepatitis B virus (HBV) achieved an 85% reduction in covalently closed circular DNA (cccDNA) and a 77% reduction in hepatitis B surface antigen (HBsAg) in HBV-infected primary human hepatocytes (PHH).

Published online in Molecular Therapy, "Targeting the Hepatitis B cccDNA with a Sequence-Specific Arcus Nuclease to Eliminate Hepatitis B Virus In Vivo," shows Precision BioScience's potential drug candidate PBGENE-HBV used in conjunction with its Arcus platform may eliminate virus persistence in patients with chronic hepatitis B.

The researchers evaluated Arcus in vivo by developing novel mouse and non-human primate models that used an episomal adeno-associated virus (AAV) containing a portion of the HBV genome to serve as a surrogate for cccDNA. A lipid nanoparticle containing Arcus mRNA was administered and in addition to the 85% decrease in the cccDNA surrogate in both episomal models, the researchers noticed a 96% reduction of HBsAg in mice. In addition, the optimized specificity of the Arcus nuclease completely prevented detectable chromosomal translocations in the PHH model, according to Precision BioSciences.

The research was conducted in collaboration with Gilead Sciences and Acuitas Therapeutics.

Copyright © 2022
To access all The ScienceBoard content create a free account now:

Email Address:  

First Name:

Last Name:

Letter from the Editor Please send me twice-weekly roundups of all the latest life research and industry news.
SAB Announcements Please send me the latest announcements from The Science Advisory Board and their partners.
Spotlight Receive notifications about new content, services, or educational resources designed to help you sharpen your skills and grow professionally.
I have read and agree to the privacy policy and terms of service and wish to opt-in for

Already have an account? Sign in here