The antibody, SRF114, is a fully human immunoglobulin G1 (IgG1) anti-CCR8 antibody that selectively depletes immunosuppressive tumor T regulatory cells (Tregs) while sparing peripheral Tregs.
The ActivMab platform is a proprietary mammalian cell-based antibody discovery and viral display platform that can be used for discovery of antibodies specific for complex membrane antigens, discovery of antibodies with optimized developability, and protein optimization for expression and activity, according to Vaccinex.
Under the agreement, Surface Oncology will pay technology access and licensing fees in addition to research funding of an undisclosed amount. Vaccinex will also qualify for development and milestone payments and royalties on the product.
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