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European cancer drug approvals under scrutiny for high risk of bias
September 19, 2019 -- Nearly half of all cancer drugs approved in Europe between 2014 and 2016 were deemed high risk of bias, indicating treatment effects may have been exaggerated. These were the findings of a study conducted by researchers at 7 institutions in the UK and US and published in BMJ on September 18.  Discuss
Personalized disease models help to fight pediatric cancers
September 19, 2019 -- Researchers at Cedars-Sinai have developed a new rapid technique the genetically modify mice to produce personalized animal models, for example, pediatric glioma.  Discuss
Novel "death star" nanoparticle discovered for potential use in targeted therapies
September 18, 2019 -- A novel nanoparticle has been reported by researchers at San Diego State University with the potential to serve as a delivery system for therapeutics. The research published on September 17 in eLife describes how Metamorphosis Associated Contractile structures (MACs) trigger metamorphosis in tubeworms. Moreover, they identify a novel protein (with syringe-like structures, nicknamed Death Star for the effect it has) responsible for the activation of metamorphosis.  Discuss
Repurposed drug shows potential to slow neurodegeneration in Parkinson's disease patients
September 17, 2019 -- Collaborative research from the University of Iowa and researchers in China and Spain, show evidence that a current drug used to treat prostate cancer may improve Parkinson's disease (PD) symptoms by slow neurodegeneration. The results from experimental models and clinical database analysis were published on September 16, in the Journal of Clinical Investigation.  Discuss
Chemists develop new technique to build super-active catalysts
September 13, 2019 -- New highly desirable catalysts, made mostly of precious metals, have 24 different faces that present atoms at the surface in ways that make them more catalytically active than current commercially available products.  Discuss
Is nanomedicine a feasible option for the pharmaceutical industry? – from the 4th Peptide Drug Design & Delivery Summit
September 12, 2019 -- The use of nanoparticles in the pharmaceutical industry is a topic of hot debate among scientists. At the 4th Annual Peptide Drug Design and Delivery Summit, August 27 -29 in Philadelphia, PA, researchers discussed the merits and challenges of incorporating these molecules into therapies.  Discuss
Science Board Member Spotlight: Mona Batish, PhD
September 11, 2019 -- The Science Advisory Board is pleased to bring you a new series that focuses on the most essential part of the scientific process: you!
Germline genetic testing in breast cancer patients may lead to increased therapy options
September 11, 2019 -- Genetic testing for metastatic breast cancer patients may play a key role in identifying additional patients with increased risk and their response to targeted therapies.  Discuss
Breakthrough electrochemical technique may bring cost savings to drug companies
September 10, 2019 -- Researchers have developed a simple new method for the creation of hindered ether compounds, which are often important components of many drugs and commercial products. Hindered ethers have been traditionally difficult to manufacture, but scientists at Scripps Research have published a new electrochemistry technique in Nature on September 9, which allows these compounds to be produced faster and more efficiently.  Discuss
New targeted therapy for lung cancer using precious metals as Trojan exosomes
September 9, 2019 -- Researchers at the University of Edinburgh and the Universidad de Zaragoza in Spain present a novel therapeutic approach to treating cancer on September 9. The research using exosome-directed catalyst prodrug therapies was published in Nature Catalysis.  Discuss
The drug development industry is hungry for 3D printing – from the 4th Peptide Drug Design & Delivery Summit
September 6, 2019 -- The Science Advisory Board attended the 4th Annual Peptide Drug Design and Delivery Summit in Philadelphia from August 27 to 29. One of the most discussed topics at the event of the use of 3D printing for pharmaceutical applications. Many scientists are pursuing this technology with gusto, utilizing the technology to improve peptide drug design.
Study identifies new therapeutic targets to help patients with lung cancer
September 5, 2019 -- A research team at Johns Hopkins University identified new therapeutic targets that will help increase the efficacy of current immunotherapies and reduce the side effects in patients with lung cancer. The results of this clinical study were published in The Journal of Clinical Investigation on September 4.  Discuss