Viral geometry mystery solved, or at least they have a theory September 27, 2019 -- A new theory, published in Nature Communications on September 27, accurately predicts the positions of proteins within icosahedral (twenty-sided) protein containers of viruses. Researchers at the University of York in the UK and San Diego State University in the US state that this discovery revolutionizes scientific understanding of how viruses form, evolve and infect hosts.
Form-switching bacteria may cause antibiotic resistance September 26, 2019 -- For the first time, scientists have confirmed that bacteria can change forms to avoid being targeted by antibiotics in the human body. Researchers from Newcastle University used state-of-the-art technology to identify bacteria with this unique characteristic. They show, in a study published in Nature Communications on September 26, that these bacteria can survive without a cell wall, potentially leading to antibiotic resistance. Discuss
Super-resolution imaging characterizes individual synaptic proteins September 26, 2019 -- It is now possible to rapidly image synaptic proteins at high-resolution thanks to a new technique developed by researchers at MIT and the Broad Institute of Harvard. Details of the technique which use fluorescent nucleic acid probes to label different proteins are described the September 26 Nature Communications article. Discuss
Exploring new tools with class 1 CRISPR systems September 23, 2019 -- A biomedical engineering collaboration between researchers at Duke University and North Carolina State University explores new frontiers of CRISPR technology utilizing the less well-known class 1 CRISPR system. The study was published in Nature Biotechnology on September 23. Discuss
European cancer drug approvals under scrutiny for high risk of bias September 19, 2019 -- Nearly half of all cancer drugs approved in Europe between 2014 and 2016 were deemed high risk of bias, indicating treatment effects may have been exaggerated. These were the findings of a study conducted by researchers at 7 institutions in the UK and US and published in BMJ on September 18. Discuss
Novel "death star" nanoparticle discovered for potential use in targeted therapies September 18, 2019 -- A novel nanoparticle has been reported by researchers at San Diego State University with the potential to serve as a delivery system for therapeutics. The research published on September 17 in eLife describes how Metamorphosis Associated Contractile structures (MACs) trigger metamorphosis in tubeworms. Moreover, they identify a novel protein (with syringe-like structures, nicknamed Death Star for the effect it has) responsible for the activation of metamorphosis. Discuss
Repurposed drug shows potential to slow neurodegeneration in Parkinson's disease patients September 17, 2019 -- Collaborative research from the University of Iowa and researchers in China and Spain, show evidence that a current drug used to treat prostate cancer may improve Parkinson's disease (PD) symptoms by slow neurodegeneration. The results from experimental models and clinical database analysis were published on September 16, in the Journal of Clinical Investigation. Discuss