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Nanoparticles eat cardiovascular plaques from the inside out
January 29, 2020 -- Scientists have engineered a nanoparticle that eats plaques associated with cardiovascular disease -- from the inside out. This Trojan horse technology could offer a new therapeutic option for the treatment of atherosclerosis, according to a study published in Nature Nanotechnology on January 27.  Discuss
Stem cell findings help researchers learn about early-onset Parkinson's
January 27, 2020 -- New research utilizing stem cells indicates that the metabolic processes that lead to young-onset Parkinson's disease could begin years before symptoms of the disease emerge. But the findings also point to a potential drug candidate that could be used to treat the condition, according to a study published January 27 in Nature Medicine.  Discuss
Microscopy with fluorescent tags gives high-def view of diabetes-related proteins
January 24, 2020 -- Leveraging the power of new imaging techniques, scientists are using unique fluorescent tags in combination with superresolution microscopy to gain novel insights into a receptor that plays a key role in controlling blood sugar levels. These insights will open the door to improved treatment options for type 2 diabetes.  Discuss
New study offers hope for short-circuiting KRAS-driven lung cancers
January 23, 2020 -- The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22.  Discuss
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
January 22, 2020 -- A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration.  Discuss
Yeast metabolism may offer lessons on starving cancer cells
January 21, 2020 -- Scientists may have found a new way to starve cancer cells by learning from growth regulation mechanisms employed by yeast. They found that the same metabolic mechanism used by yeast to respond to nutrient shortages is also employed by mammalian cells -- a finding that could lead to new cancer therapies, according to a new study published in Nature Metabolism on January 20.  Discuss
Scientists in the Lab: Featuring Rajan Chaudhari
January 21, 2020 -- We are thrilled to introduce our next laboratory scientist this month, who works at the intersection of chemistry, drug development, and data science. Rajan Chaudhari, PhD, is a postdoctoral fellow at the University of Texas MD Anderson Cancer Center in Houston.  Discuss
Researchers tackle fake medicine with uncrackable puzzles
January 20, 2020 -- Protecting patients from consuming counterfeit medicines is an urgent need. A new uncrackable authentication system is being developed with the use of degradable fluorescent proteins. Researchers from Purdue University are developing edible "security tags" that can be embedded on medicines. The work was published in Nature Communications on January 16.  Discuss
Correlative microscopy provides view of subcellular components
January 17, 2020 -- As technology improves and knowledge of molecular biology increases, there is a need to view and analyze the complex organization of cells. That's become possible thanks to a new methodology based on correlative microscopy, which uses a combination of fluorescence and electron microscopy to seamlessly zoom in and out of a sample. The protocol was described in Science on January 17.  Discuss
Even scientists need to build their online brand
January 16, 2020 -- Maybe you entered science because you were more interested in the pursuit of knowledge than in business applications like sales and marketing. But even scientists need to market themselves by building their online brand. Fortunately, today's social media tools can help you do so easily.  Discuss
Scientists learn how lactate contributes to cancer formation
January 15, 2020 -- Previously considered a waste product of metabolism, lactate may play a crucial role in cancer growth, according to a study published in Frontiers in Oncology on January 14. Researchers from the University of Colorado Anschutz Medical Campus explored how lactate affects transcription of oncogenes in breast cancer cells.  Discuss
Scientists in the Lab: Featuring Lisa Mustachio
January 15, 2020 -- Continuing our feature series this January, ScienceBoard is happy to highlight the work of laboratory scientists, including Lisa Maria Mustachio, PhD, a postdoctoral fellow at MD Anderson Cancer Center.  Discuss
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