Proteomics
SARS-CoV-2 envelope protein identified as target for antiviral drugs
Comparison of the SARS-CoV-2 genome with other betacoronaviruses can provide useful information on how drugs targeting other coronaviruses may improve outcomes for COVID-19 patients. The analysis was presented in a July 27 Frontiers in Cellular and Infection Microbiology article.  Discuss
SARS-CoV-2 disguises its own genetic material to facilitate infection
The SARS-CoV-2 virus is able to camouflage itself to promote viral replication, as revealed by structural details of proteins on the surface of the virus. Researchers discovered an enzyme that they believe could be an important target for antiviral drug development, according to a July 14 Nature Communications report.  Discuss
Life science instrumentation market adapts to COVID-19
To reflect the new realities of the analytical instrumentation market during the COVID-19 pandemic and in the subsequent pandemic-driven recession, Strategic Directions International, a sister company of The Science Advisory Board, has released its revised edition of the Global Assessment Report.  Discuss
Pall debuts solution for biotech research
Pall, one of the largest suppliers of laboratory filtration and clarification products, recently launched two new filtration and clarification plates designed to improve cell and protein purification.  Discuss
Unveiling bat secrets of immunity could offer clues to treating COVID-19
Bats' longevity and capacity to tolerate viruses may stem from their ability to control inflammation, according to a review article published in Cell Metabolism on July 7. The unique mechanisms that bats employ to achieve this may hold clues to developing new treatments for human diseases.  Discuss
How has SARS-CoV-2 evolved from bat coronavirus?
Structural comparison between a bat coronavirus and SARS-CoV-2 reveals specific characteristics that make the new virus more pathogenic, according to a new article published in Nature Structural and Molecular Biology on July 9.  Discuss
SARS-CoV-2 rewires host proteins to promote infection
To successfully infect human cells, SARS-CoV-2 may hijack host proteins in target cells to promote its own replication. Researchers may be able to leverage this information to identify and recommend drugs, according to a June 29 Cell article.  Discuss
DNA 'origami' informs coronavirus vaccine design
Strategically folded DNA arranged to mimic viral antigens -- known as DNA "origami" -- may produce strong immune responses, according to a June 29 report in Nature Nanotechnology. Researchers are now working on adapting this approach for the development of a vaccine against SARS-CoV-2.  Discuss
Getting to the heart of SARS-CoV-2 protease; a main drug target
X-ray crystallography performed at room temperature of the main protease of SARS-CoV-2 may be more physiologically relevant than standard low-temperature x-ray structures, according to a June 24 report in Nature Communications.  Discuss
Computer tools shorten development time for SARS-CoV-2 drugs
Computer-based tools are helping researchers find potentially promising candidates for vaccines and treatments for SARS-CoV-2 -- and much more quickly than traditional approaches. Many of these software tools are described in an article published June 24 in Science Advances.  Discuss
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