Proteomics
Improving melanoma immunotherapies by regulating Treg proliferation
A new pathway to regulating anti-tumor immunity and increasing the effectiveness of PD-1 therapies was identified by scientists at Sanford Burnham Prebys Medical Discovery Institute. The results were published in Nature Communications on January 7.  Discuss
Researchers elucidate mechanotransduction pathways of transmembrane proteins
Researchers from Imperial College London, Queen Mary University of London, and Tampere University in Finland present new mechanistic pathways for transmembrane proteins with implications in drug discovery and development. The results of the study were published in Nature Materials on January 6.  Discuss
Researchers work out the early steps that drive malignancy
Researchers from Yale University have identified cellular characteristics that lead to the early stages of malignancy. They state that in at least one form of blood cancer, cells with cancer-causing lesions can remain normal until cell division speeds up the process. The results were published in Nature Communications on December 18.  Discuss
Algorithm provides new insight into hierarchical DNA structures that influence disease
Researchers develop an algorithm that locates specific topologically associating domains (TADs) which are implicated in disease development, including cancer. The technology, called OnTAD, can examine internal architectures of TADs, which are important in elucidating their biological functions. The work was published in Genome Biology on December 18.  Discuss
New drug target identified in malaria transmission
Australian researchers from the University of Melborne and Griffith University in Queensland have confirmed their findings of a new drug target that blocks the transmission of Plasmodium falciparum in mosquitos. The results were published in Cell Reports on December 17.  Discuss
Researchers explore the role of circular DNA in deadly childhood cancer
Researchers from Charité - University Medicine Berlin and the Memorial Sloan Kettering Cancer Center in New York combine genomic and transcriptomic approaches to describe the landscape of extrachromosomal circular DNA in neuroblastoma. The work was published in Nature Genetics on December 16.  Discuss
Leveraging new technologies to push the boundaries of our knowledge of cell biology
At the American Society of Cell Biology, European Molecular Biology Organization Joint Meeting in Washington, DC from December 7-11, emerging topics and new technologies were discussed and highlighted. Proteomics and genomics seemed to be a focus of the meeting. Many researchers presented novel ideas to incorporate new technologies in these fields to make discoveries in cell biology.
New microscopy technique helps scientists understand cancer growth and spread
Researchers from Duke Cancer Institute have developed a new technique to observe stem cell mutations occurring in colon cancer.  Discuss
Algorithm detects unknown anomalies in RNA-seq data
A new computational approach to analyzing gene expression data is presented by computational biologists from Carnegie Mellon University (CMU) and published in Cell Systems on November 27.  Discuss
Data Science Vital to Large-Scale Cellular Studies
Data science as a discipline has become a central aspect of many commercial endeavors. A large range of distinct applications have adopted its approaches and techniques. Despite the major differences in many of these applications, some of the techniques can be transferred from old and established data-driven fields to new, completely separate data-intensive areas. For example, certain image analysis algorithms from astronomy can be applied in fields involving microscopy.  Discuss
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