Life Science Informatics
Precision medicine and molecular understanding of illness
The current era of scientific research is seen by many as a golden age of discovery in genetics, due to rapid progress in numerous areas of science and technology. While healthcare and the pharmaceutical industry traditionally have directed their attention to symptoms rather than underlying causes, the new advances are creating opportunities to better exploit a rapidly expanding mechanistic understanding of disease. The challenges are significant and complex, and the current models of discovery and translation do not provide an obvious path toward an economically sustainable way to integrate data-intensive biology with medicine.  Discuss
Algorithm provides new insight into hierarchical DNA structures that influence disease
Researchers develop an algorithm that locates specific topologically associating domains (TADs) which are implicated in disease development, including cancer. The technology, called OnTAD, can examine internal architectures of TADs, which are important in elucidating their biological functions. The work was published in Genome Biology on December 18.  Discuss
Algorithm detects unknown anomalies in RNA-seq data
A new computational approach to analyzing gene expression data is presented by computational biologists from Carnegie Mellon University (CMU) and published in Cell Systems on November 27.  Discuss
Researchers use drug repurposing to identify new treatment for Metabolic Syndrome
A research team from the University of Trento find a novel method for using old drugs in new ways, specifically for Metabolic Syndrome. This revolutionary technique, published on November 18 in Nature Communications, uses a systems biology approach to investigate deregulated biological processes and identify drug repurposing candidates.  Discuss
New model uses bioinformatics to identify aggressive breast cancers
Researchers from the University of Bonn propose a new method to determine the prognosis of disease using the patients' tumor tissue. The results were published in Cell Reports on October 29.  Discuss
Dementia-associated atrophy predicted by brain networks
A new study uses brain maps to predict how brain atrophy spreads in patients with frontotemporal dementia (FTD). The experiment, conducted by UC San Francisco scientists, adds to a growing body of data suggesting that brain cell loss associated with dementia spreads via synaptic connections between established brain networks.  Discuss
DNA Metabarcoding used to analyze human diet
A collaborative study from US researchers demonstrates that DNA metabarcoding has promise for characterization of human diets. The research, which was published in mSystems on October 8, provides evidence that DNA sequencing-based approaches can be successfully applied to human samples.  Discuss
New synthetic vaccine fights infectious disease with assistance from the data cloud
A new synthetic vaccine developed by researchers at the University of Bristol and the French National Centre for Scientific Research can be stored at warmer temperatures due to an engineered scaffold design. The details of the Chikungunya vaccine candidate are published in Science Advances on September 25.  Discuss
Genomic and microbial analyses reveal microbe independently degrades oil to gas
Methanoliparia, an archaea found in deep within oil reservoirs, may degrade oil to methane all by itself. Researchers from the Max Planck Institute for Marine Microbiology in Bremen, Germany and the MARUM, Centre for Marine Environmental Sciences provide genomic and microbial evidence of Methanoliparia‚Äôs ability to transform long-chain hydrocarbons to methane. The results were published in mBio on August, 20.  Discuss
Large-scale analysis of microbiome reveals new classes of small proteins with implications in drug discovery
Trillion of bacteria reside within our bodies, and scientists are just scratching the surface of understanding the microbiome. Researchers at Stanford School of Medicine have shed light on previously unidentified proteins that may have an important role in human health and advance drug development.  Discuss
Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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