Genomics
Long-read sequencing of circRNA finds autism-linked microexons
Scientists have developed a new laboratory protocol and bioinformatic pipeline using a long-read sequencing platform from Oxford Nanopore Technologies for exploring the composition of circular RNA (circRNA). The technique, published on August 10 in Nature Communications, showed that a group of microexons that had been previously linked to autism are preferentially found in circRNA. Read More
Researchers call for improved reporting of environmental conditions in cell culture
There is an urgent need to improve the reporting of environmental conditions for mammalian cell culture experiments for biomedical research, according to a comment published in Nature Biomedical Engineering on August 13. Read More
PerkinElmer releases new KRAS investigation kits
PerkinElmer has released four new test kits designed to help researchers better understand KRAS protein structures and mutations. The kits will enable cancer researchers to accelerate the identification and optimization of therapeutic leads, the company said. Read More
Mirus Bio introduces viral vector manufacturing reagents
Mirus Bio announced an expansion of its TransIT VirusGen platform that is compliant with good manufacturing practices viral vector manufacturing to support cell and gene therapy development, process activities, and commercial production. Read More
Researchers debunk myth that high drug prices are necessary for innovation
A new analysis of publicly reported financial information from pharmaceutical companies found that reducing drug prices would have no impact on R&D innovation and future drug approvals. The findings were published in a white paper titled "Will Reducing Drug Prices Slow Innovation?" on August 9. Read More
Alternative gene therapies could be effective in treating some rare diseases
Bacteria-mediated genetic transfer has emerged as an alternative gene therapy (AGT) for the treatment of some rare diseases, such as phenylketonuria (PKU). This type of therapy is advantageous because it is easily regulated through established protein expression systems. One company, Synlogic, has developed an AGT candidate that uses a bacterial vector to treat PKU. Read More
Prime editing shows promise for complex diseases like cystic fibrosis
Researchers have demonstrated that prime editing -- a newer version of CRISPR-Cas9 gene editing -- can be successfully employed to correct gene mutations that cause cystic fibrosis. The new study, which tested the technique in human organoids, was published in Life Science Alliance on August 9. Read More
Voyager advances gene therapy platform for CNS diseases
Voyager Therapeutics has launched new gene therapy programs for Huntington's disease, amyotrophic lateral sclerosis caused by mutation in the SOD1 gene, spinal muscular atrophy, and diseases linked to glucosylceramidase beta mutations, powered by its proprietary adeno-associated virus capsids. Read More
Researchers identify chronic stress gene target in brain
By studying how genes affect receptors in the brain under stress, researchers have discovered new molecular mechanisms behind the function of corticosterone, the stress hormone. The research was published in Nature Communications on August 6. Read More
New sequencing workflow efficiently maps protein-protein interactions
A new tool called protein-protein interaction sequencing (PROPER-seq) allows researchers to map complex networks of proteins within cells of interest without the need for specialized resources, like antibodies or premade gene libraries. The methodology was published in Molecular Cell on August 3. Read More
Conferences
Building Biology in 3D Hybrid Symposium
October 26-27
La Jolla, California United States
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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