Genomics
Phages containing huge amounts of DNA are found around the globe
An inventory of over 350 DNA sequences from phage genomes revealed that these genomes can be over 200,000 base pairs in length and found the largest phage genome ever described at 735,000 base pairs in length. The report published in Nature on February 12, evaluated the prevalence, diversity and ecosystem distribution of phages with large genomes. Read More
CRISPR proteins developed for use in molecular diagnostics
New CRISPR technology is being developed as a molecular diagnostic tool with the capability of detecting unique disease biomarkers. Eventually, these at-home tests will allow patients to conduct at-home diagnostic tests quickly. Read More
Genomics sheds light on the life history of cancers
As part of a special collection of papers on pan-cancer analysis of whole genomes published online by Nature on February 6, an international group of scientists analyzed over 2,500 unique cancer genomes to shed light on the life history of cancer mutations and how cancer tumors evolve -- even before they are diagnosed. Read More
Chinese researchers mobilize to classify 2019-nCoV
In response to a recent outbreak of the novel coronavirus (2019-CoV), scientists in China have uncovered genetic similarities with severe acute respiratory syndrome (SARS) coronaviruses by analyzing patient samples from the source of the outbreak. Their findings provide crucial evidence that will aid in the classification and identification of 2019-CoV, according to a new report published in Nature on February 3. Read More
Institut Pasteur reveals how it sequenced the coronavirus
On January 30, the Institut Pasteur became the first European institution to sequence the novel coronavirus (2019-nCoV) since the outbreak began in December 2019. Institut Pasteur researchers used a unique sequencing platform to confirm the presence of 2019-nCoV in three samples from suspected cases in France. Read More
NGS of China coronavirus shows bat origins, intermediate host
Next-generation sequencing (NGS) of 10 genomes of novel coronavirus (2019-nCoV) from nine patients in China demonstrated that the virus is closely related to two coronaviruses that originated in bats, but that an intermediate host may be responsible for the spread to humans, according to a study published in Lancet on January 29, 2020. Read More
Enrichment NGS emerges as surveillance tool for coronavirus
As the coronavirus continues to grow as a global health concern, researchers urgently seek efficient methods to predict and mitigate emerging coronavirus strains. An international team of researchers believes that targeted next-generation sequencing (NGS) may be a valuable tool for monitoring both current and future outbreaks of coronavirus originated from bats. Read More
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22. Read More
Yeast metabolism may offer lessons on starving cancer cells
Scientists may have found a new way to starve cancer cells by learning from growth regulation mechanisms employed by yeast. They found that the same metabolic mechanism used by yeast to respond to nutrient shortages is also employed by mammalian cells -- a finding that could lead to new cancer therapies, according to a new study published in Nature Metabolism on January 20. Read More
Researchers work out the early steps that drive malignancy
Researchers from Yale University have identified cellular characteristics that lead to the early stages of malignancy. They state that in at least one form of blood cancer, cells with cancer-causing lesions can remain normal until cell division speeds up the process. The results were published in Nature Communications on December 18. Read More
Conferences
Northeast Regional Laboratory Staff and Core Directors (NERLSCD) 2021
November 3-5
Portsmouth, New Hampshire United States
CPhI Worldwide 2021
November 9-11
Milan, Lombardia Italy
Society for Immunotherapy of Cancer (SITC) Annual Meeting
November 10-14
Washington, DC, District of Columbia United States
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