Cellecta releases NGS assays for T-cell and B-cell receptor chains
Genomics company Cellecta announced on Wednesday that it has launched its DriverMap Adaptive Immune Receptor DNA (AIR-DNA) TCR and BCR kits that provide rapid, single-tube polymerase chain reaction (PCR) analysis of the variability of T-cell and B-cell receptor chains from a range of sample types, including tissue biopsy, whole blood, purified immune cells, and others. Read More
Genetically engineered probiotic keeps mice sober, protects liver after alcohol exposure
A genetically engineered probiotic has accelerated recovery from alcohol exposure in mice, suggesting the approach could mitigate hangovers and adverse outcomes associated with excessive consumption. Read More
Dialing down activity of Cas enzyme improves safety of CRISPR gene editing in mice
Scientists have modified the synthetic guide RNA (gRNA) that enables CRISPR-Cas gene editing to make the process safer for use in humans. Read More
RNA biomarkers may help confirm heart disease, study finds
An analysis of blood RNA from patients with angiographically confirmed coronary artery disease has shown how RNA biomarkers may be used to confirm heart disease. Read More
Riboswitches enable small molecules to regulate activity of anemia gene therapy in mice
Astellas Pharma has helped develop a system for using small molecules to regulate gene expression that could improve the safety of gene therapies. Read More
What to do when genetic tests reveal links to cardiovascular disease: Scientific statement
Increased use of genetic testing means that people may discover they have an incidentally-found genetic abnormality, or gene variant, associated with cardiovascular disease (CVD), according to a scientific statement published Monday in the American Heart Association journal Circulation: Genomic and Precision Medicine. Read More
Shared genetic markers linked with substance use disorders
By combing through genomic data from more than one million people, scientists have identified genes commonly inherited across addiction disorders, regardless of the substance being used. Read More
RNA-seq analysis links protein to spread of pancreatic cancer, reveals potential drug target
An analysis of 400 pancreatic cancer tumor samples has linked a protein that controls RNA processing to the formation of metastases, suggesting that it may be possible to delay the spread of the cancer. Read More
CRISPR/Cas9 mouse model reveals cellular function changes that drive rare disease
A CRISPR/Cas9 mouse model has shown how mutations that cause a rare disease affect cellular function, shedding light on how to monitor and treat the condition in the process. Read More
Correlation of enzyme to survival reveals potential target for metastatic solid tumors
The enzyme lysyl hydroxylase 1 (LH1) promotes the migration and metastasis of solid tumor cells and is associated with shorter survival, according to a recent study published in Molecular Cancer. Read More
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