Drug Discovery & Development
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22. Read More
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration. Read More
Scientists in the Lab: Featuring Rajan Chaudhari
We are thrilled to introduce our next laboratory scientist this month, who works at the intersection of chemistry, drug development, and data science. Rajan Chaudhari, PhD, is a postdoctoral fellow at the University of Texas MD Anderson Cancer Center in Houston. Read More
Researchers tackle fake medicine with uncrackable puzzles
Protecting patients from consuming counterfeit medicines is an urgent need. A new uncrackable authentication system is being developed with the use of degradable fluorescent proteins. Researchers from Purdue University are developing edible "security tags" that can be embedded on medicines. The work was published in Nature Communications on January 16. Read More
Scientists learn how lactate contributes to cancer formation
Previously considered a waste product of metabolism, lactate may play a crucial role in cancer growth, according to a study published in Frontiers in Oncology on January 14. Researchers from the University of Colorado Anschutz Medical Campus explored how lactate affects transcription of oncogenes in breast cancer cells. Read More
Scientists in the Lab: Featuring Lisa Mustachio
Continuing our feature series this January, ScienceBoard is happy to highlight the work of laboratory scientists, including Lisa Maria Mustachio, PhD, a postdoctoral fellow at MD Anderson Cancer Center. Read More
Control of molecular 'doormen' in fat cells offers potential new obesity treatment
New treatment options for obesity could emerge from a study published in Nature Communications on January 10. Researchers from Yale University School of Medicine utilized cellular and molecular approaches to identify pathways to restore the healthy balance of fat cells. Read More
Bacterial evolution reveals method to fight antibacterial resistance
Different types of bacteria have evolved to develop unique mechanisms for achieving the same antibacterial function -- a finding that could lead to new ways to combat antibacterial resistance, according to scientists from Trinity College Dublin. They tested their findings using methicillin-resistant Staphylococcus aureus in a study that was published in Nature Communications on January 9. Read More
Nanoparticles direct 'suicide genes' to treat brain tumors in children
Researchers from Johns Hopkins University report a bioengineered nanoparticle that successfully delivers a "suicide gene" to pediatric brain tumor cells implanted in the brains of mice. Details of the nanoparticle treatment were published in the January 2020 edition of Nanomedicine: Nanotechnology, Biology and Medicine. Read More
Improving melanoma immunotherapies by regulating Treg proliferation
A new pathway to regulating anti-tumor immunity and increasing the effectiveness of PD-1 therapies was identified by scientists at Sanford Burnham Prebys Medical Discovery Institute. The results were published in Nature Communications on January 7. Read More
Conferences
BioTech Pharma Summit
September 27-28
Porto Portugal
Infectious Diseases (ID) Week 2021
September 29 - October 3
San Diego, California United States
Imaging Mass Spectrometry Society (IMSS) 3 in 2021
October 3-6
Colorado Springs, Colorado United States
Cell & Gene Meeting on the Mesa
October 10-14
Carlsbad, California United States
Connect
Science Advisory Board on LinkedIn
Science Advisory Board on Facebook
Science Advisory Board on Twitter