Drug Discovery & Development
Scientists connect gene to cancer metastasis for the first time
Researchers have identified new functionality of a previously underappreciated gene, leucine-rich repeat neuronal 4 C-terminal like (LRRN4CL), which is overexpressed in melanoma cells. They believe LRRN4CL plays an important role in cancer metastasis to the lungs and describe their findings in Communications Biology on March 23. Read More
Hydrogen maps of SARS-CoV-2 main protease point to effective repurposed drugs
Scientists have used atomic maps of hydrogen atoms to determine that the SARS-CoV-2 main protease acts in unexpected ways when it comes into contact with a drug inhibitor. The research, published in the Journal of Medicinal Chemistry on March 23, provides key insights for efforts to repurpose existing drugs to develop candidates for treating COVID-19. Read More
Gene therapy based on transcription factors could be effective against Alzheimer's
A type of gene therapy using transcription factors to target DNA has been shown to dramatically reduce levels of the harmful protein tau in preclinical mouse models of Alzheimer's disease. The findings, published in Science Advances on March 19, suggest that the therapy could easily translate to the clinic and be effective in humans. Read More
What pregnant women need to know about COVID vaccines
Addressing questions about COVID-19 vaccines for pregnant and postpartum women, a leading maternal-fetal medicine specialist explained that it's likely best to get vaccinated as soon as they are eligible. Read More
Scientists uncover secrets to controlling gene expression
Bioengineers have demonstrated that simultaneous control over transcription and translation in cells can achieve the most stringent control of gene expression to date. The findings, published in Nature Communications on March 19, will open new avenues for improved biotechnologies and synthetic biology applications. Read More
Stable spike protein makes main SARS-CoV-2 variant more infectious
A new study finds that the enhanced infectivity of the dominant G614 variant of the SARS-CoV-2 virus largely results from the increased stability of its spike protein. Findings from the study were published in Science on March 16. Read More
SARS-CoV-2 PLpro enzyme may be an effective COVID-19 drug target
A coronavirus enzyme called papain-like protease (PLpro) that's capable of blocking host innate immune responses during infection may be an attractive COVID-19 target for therapy drug candidates, according to a new study published March 16 in Nature Microbiology. Read More
New intestine chips promote precision in preclinical models
A new intestine-on-a-chip platform enables researchers to model host-microbiome relationships to gain new insights into the mechanisms of infectious disease in the body, according to a new study published in Frontiers in Cellular and Infectious Microbiology on March 12. Read More
RNA editing enzyme ADAR1 helps cancer cells proliferate
Researchers have discovered that an isoform of the RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is responsible for regulating genome stability of telomeres at chromosomal ends. The findings, published in Nature Communications on March 12, suggest that the enzyme is required for the proliferation of cancer cells and may be a potential therapeutic target for some cancers. Read More
Can a single dose of a vaccine designed as 2 doses be effective?
Researchers suggested that two doses of a COVID-19 vaccine are more protective than a single dose, even if the interdose period is longer than recommended. The study's results, published in Science on March 9, indicate that the effect of vaccines on the spread and mutation of SARS-CoV-2 is reliant on relative robustness of immunity conferred by a single dose. Read More
Conferences
Laboratory Products Association Annual Meeting
October 1-4
Scottsdale, Arizona United States
Cell & Gene Meeting on the Mesa
October 11-13
Carlsbad, California United States
IDWeek 2022
October 19-23
District of Columbia United States
American Society of Human Genetics Annual Meeting
October 25-29
Los Angeles, California United States
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