Drug Discovery & Development
Large-scale analysis of microbiome reveals new classes of small proteins with implications in drug discovery
Trillion of bacteria reside within our bodies, and scientists are just scratching the surface of understanding the microbiome. Researchers at Stanford School of Medicine have shed light on previously unidentified proteins that may have an important role in human health and advance drug development.  Discuss
New immunotherapy moves further into clinical testing with promising results
Success in international clinical trials leads to U.S. based research organizations beginning phase I/II clinical trials. If this form of immunotherapy is successful and deemed safe, then it could save the lives of liver cancer patients across the world.  Discuss
Structure-based vaccine design may help save the lives of infants and children
A new experimental vaccine, utilizing structure-based design, shows promise in a phase I clinical trial. The vaccine will protect against respiratory syncytial virus (RSV), a leading cause of infectious disease deaths in infants. Researchers at the University of Texas at Austin published findings on Aug 2, 2019 in Science stating that one dose elicited increases in RSV-neutralizing antibodies over several months.  Discuss
A bright new tactic in the fight against cardiovascular disease
A new system using reporter proteins has been developed by researchers at Carnegie, Johns Hopkins University, and the Mayo Clinic that uses high-throughput genetic and small-molecule screening, as well as whole-organism imaging to find new drugs for the treatment of cardiovascular disease. These results which provide insights into heart disease were published in Nature Communications on July 31, 2019.  Discuss
Finding the next generation of antibiotics may require the use of NGS sequencing and genome mining
Determining how antibiotic structures are formed in nature is crucial knowledge that scientists will leverage in the development of the next generation of antibiotics. Researchers from Washington University in St. Louis and the University at Buffalo published the X-ray crystal structure of an enzyme that produces a candidate antibiotic in Nature Communications on July 31, 2019.  Discuss
Genome mining has potential uses in synthetic biology and drug discovery
Researchers discovered a cluster of genes in Pseudomonas syringae which infects plants. The results of this research were published in Science on July 19th. However, this natural product produced belongs to a special class of ribosomally synthesized and posttranslationally modified peptides.  Discuss
The European Commission pursues open science and why it’s important
Scientists believe that there is a reproducibility crisis in the scientific community where many scientists fail to reproduce experiments, according to a new report by Science | Business in July 2019. Open science is a high priority for the European Commission, with around 70% of all data generated by EU-funded programs being accessible to the public.  Discuss
New clinical trial testing effectiveness of anti-obesity drug in conjunction with genetic screening
A new phase 3 clinical trial expected to begin in late July 2019, will test an anti-obesity drug targeting people with rare genetic conditions, and will be tied to a genetic study attempting to create a more comprehensive understanding of the genes associated with obesity.  Discuss
Landmark study explores public understanding of science and trust in scientific and medical professionals
Understanding global perceptions and knowledge of science is of growing interest to the scientific community. Organizations such as 3M, with their State of Science Index Survey and the Wellcome Global Monitor (WGM), from the Wellcome Foundation and Gallup World Poll, explore attitudes towards science and medicine, and also confidence in scientists themselves.  Discuss
Leaders in science and engineering publications over the last decade: China and the US
Capturing the attention of policy makers and companies serving the academic research market the countries with the largest number of science and engineering (S&E) articles has significantly evolved between 2007 and 2017. China leads the list in 2017 followed by the US, a reverse from 2007, according to a May report from the NSF’s National Center for Science and Engineering Statistics.  Discuss
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September 21-25
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