Cell Biology
Major class of probiotics gets new taxonomy
A new paper published in the International Journal of Systematic and Evolutionary Microbiology proposes major changes to the classification and naming of Lactobacillus probiotics based on new information gained by modern DNA analysis tools.  Discuss
Genetically engineered probiotics successfully deliver immunotherapies
A new technology enables genetically engineered probiotic bacteria to be used as an efficacious, stable, and safe platform to deliver immunotherapies directly into a variety of tumors in just a single dose. The research was published online on February 12 in Science Translational Medicine.  Discuss
3D model of human intestines helps simulate leaky gut condition
Researchers are using 3D models of human intestines to simulate leaky gut conditions -- in which microbes and molecules seep out of the intestines, eliciting an immune response. The research, published in Life Science Alliance on February 10, will help identify biomarkers for leaky gut for improved diagnostics and treatment development.  Discuss
Dietary probiotics show potential to reverse Parkinson's symptoms
Roundworms that were fed a commercially available dietary probiotic showed less buildup of proteins that form during the progression of Parkinson's disease in a new study, published in Cell Reports on January 14. The finding provides further evidence of a link between the gut microbiome and brain function.  Discuss
Orphan immunity gene clusters acquired for protection
Researchers from the University of Washington School of Medicine and Howard Hughes Institute found that gut bacteria acquire interbacterial defense gene clusters. The October 30 article in Nature, suggests that bacteria use these toxins against their microbial neighbors. This discovery could further scientific knowledge of the human gut which is critical to many aspects of health and disease.  Discuss
Software improves the speed of identifying potential new antibiotics
Computational biologists at Carnegie Mellon University and seven other institutions developed a software tool that can play a high-speed "Match Game" to identify bioactive molecules and microbial genes that produce them so they can be evaluated as new antibiotics and other therapeutic agents. This work was published in Cell Systems on October 16.  Discuss
Scientists elucidate the genetic impact of host immune system on the microbiome
Researchers at the University of Chicago conducted research that suggests that the genetic differences in the immune system contribute to bacterial colonization of gut. The findings, published in Cell Reports on October 15, uses a new approach to determine the genetic influence of the immune system on the microbiome of mice.  Discuss
DNA Metabarcoding used to analyze human diet
A collaborative study from US researchers demonstrates that DNA metabarcoding has promise for characterization of human diets. The research, which was published in mSystems on October 8, provides evidence that DNA sequencing-based approaches can be successfully applied to human samples.  Discuss
Form-switching bacteria may cause antibiotic resistance
For the first time, scientists have confirmed that bacteria can change forms to avoid being targeted by antibiotics in the human body. Researchers from Newcastle University used state-of-the-art technology to identify bacteria with this unique characteristic. They show, in a study published in Nature Communications on September 26, that these bacteria can survive without a cell wall, potentially leading to antibiotic resistance.  Discuss
Genomic and microbial analyses reveal microbe independently degrades oil to gas
Methanoliparia, an archaea found in deep within oil reservoirs, may degrade oil to methane all by itself. Researchers from the Max Planck Institute for Marine Microbiology in Bremen, Germany and the MARUM, Centre for Marine Environmental Sciences provide genomic and microbial evidence of Methanoliparia‚Äôs ability to transform long-chain hydrocarbons to methane. The results were published in mBio on August, 20.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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