Cell Biology
Bioinformatics helps pinpoint evolutionary mutations of SARS-CoV-2
A new bioinformatics approach to classifying genetic variants of SARS-CoV-2 helps to answer questions such as whether there are one or more circulating strains of the virus with different virulence levels and, if so, which of those strains should be used for therapeutic research. Australian researchers explore this technique in an April 19 article in Transboundary and Emerging Diseases.  Discuss
Major class of probiotics gets new taxonomy
A new paper published in the International Journal of Systematic and Evolutionary Microbiology proposes major changes to the classification and naming of Lactobacillus probiotics based on new information gained by modern DNA analysis tools.  Discuss
The jury is still out for SARS-CoV-2 intermediate host
Scientists have been searching for the intermediate host between bats, which are known to carry coronaviruses, and the first introduction of SARS-CoV-2 into humans. Conflicting research argues the merit of dogs as intermediate hosts of the virus.  Discuss
Directed evolution shows promise in reducing drug discovery times
A research collaboration between scientists at the University of Leeds and AstraZeneca resulted in the development of a technique that can significantly reduce the discovery time for possible new antibody-based therapies. The approach, published in Nature Communications on April 14, shows how protein fragments can be screened for susceptibility to aggregation in early drug discovery.  Discuss
Scientists explore SARS-CoV-2 main protease as a drug target
A team of researchers report the structure of the main protease of the novel coronavirus and have identified several drugs that show promise in combating the virus, according to an April 9 article published in Nature.  Discuss
New antiviral drug could work against many viruses, including SARS-CoV-2
An antiviral drug called EIDD-2801 that's in preclinical testing has potential to be developed into the silver bullet that medical professionals seek to treat COVID-19, according to new research published in Science Translational Medicine on April 6.  Discuss
Could a MERS vaccine candidate be the answer for COVID-19?
As researchers urgently work to develop vaccines to prevent COVID-19, many strategies have been considered. Now, a parainfluenza virus 5-based vaccine expressing MERS-CoV spike protein may provide an avenue for a COVID-19 vaccine based on the similarity of the two viruses, according to a study published in mBio on April 7.  Discuss
It's time to enlist research labs in the COVID-19 fight
Careful incorporation of research laboratories into the COVID-19 testing effort could increase capacity in the U.S. and globally, writes molecular diagnostics expert Rahul Sharma, PhD, in this second opinion article.  Discuss
Are masks effective at preventing the spread of SARS-CoV-2?
Contradictory messages over the best methods to limit the spread of SARS‑CoV‑2 have been shared with the public in past months. This has prompted scientists to explore the effectiveness of certain measures like wearing masks and the mechanisms behind transmission of the virus.  Discuss
COVID-19 shuts down research labs as concern grows among scientists
Almost half of all scientific research labs that participated in a recent survey were shut down due to concerns about the COVID-19 outbreak. Survey results indicate that scientists are quite concerned and that their work is considerably impacted by the pandemic, according to a new COVID-19 scientist sentiment tracker.  Discuss
Conferences
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
BioProcess International
September 21-24
Eastern Standard Time Zone (EST), Massachusetts United States
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