Discovery of toxin linked to severe COVID-19 points to new way to treat disease
A viral toxin produced by the SARS-CoV-2 virus may damage cell barriers, inducing vascular leak and driving severe COVID-19 infections, according to researchers at the University of California, Berkeley (UC Berkeley). Read More
AI provides evidence that gene length explains age-related molecular changes
Artificial intelligence (AI) has helped Northwestern University researchers find evidence that the length of genes explains most of the molecular-level changes that occur during aging, which they contend could lead to therapeutics that slow or even reverse the process. Read More
Functional genomics reveals gateway to intracellular targets for large molecules
Complementary genome-scale, chemical-genetic approaches have revealed a cellular gateway that could allow large molecules to enter cells, providing new opportunities to develop drugs for intracellular targets, according to University of California San Francisco (UCSF) researchers. Read More
Sound waves sort extracellular vesicles to enable liquid biopsies, regenerative therapies
Duke University engineers have used sound waves to separate small extracellular vesicles from biofluids, laying the groundwork for the development of next-generation liquid biopsies and regenerative therapies. Read More
Senescent neuron discovery in brains opens path for Alzheimer's drug development
Scientists at the Salk Institute for Biological Studies have found that neurons from people with Alzheimer's disease show deterioration and undergo a late-life stress process called cellular senescence, while senescent cells could be a way to slow neuroinflammation and neurodegeneration. Read More
Single-cell fetal brain profiling uncovers potential ways to treat pediatric tumors
A multinational team of scientists has used single-cell profiling of freshly isolated human fetal tissue to reveal a reference map of the cell states of the most common malignant childhood brain cancer. Read More
Penn researchers create adrenal gland organoid using stem cells
A research team, led by the University of Pennsylvania's School of Veterinary Medicine, has used stem cells to grow an organoid in a petri dish with the characteristics and functions of a human fetal adrenal gland. Read More
Rapidly generated artificial enzymes inhibit COVID-19 infection in preclinical tests
Artificial enzymes targeting the SARS-CoV-2 genome can inhibit viral infection, pointing to a new way to rapidly develop treatments for emerging biological threats such as COVID-19. Read More
Enzyme shown to restore cell volume after exposure to external stressors
Researchers at the University of Pittsburgh and Carnegie Mellon University have shown that with-no-lysine (WNK) kinases activate a "switch" to restore cell volume after exposure to an external stressor, such as high levels of salt or sugar. Read More
New computational method maps architecture of human tissues in unprecedented detail
Weill Cornell Medicine researchers have developed a new computational method to map the architecture of human tissues in unprecedented detail, with the potential to accelerate studies on organ-scale cellular interactions and enable powerful new diagnostic strategies for an array of diseases. Read More
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