Cancer & Disease Research
Small-molecule chaperones may reverse Alzheimer's symptoms in mice
A novel treatment for Alzheimer's disease involving the administration of pharmacological chaperones that prevent amyloid beta and tau tangles from forming in the brain may be possible, according to a new study published online on January 22 in Molecular Neurodegeneration. Read More
Dietary probiotics show potential to reverse Parkinson's symptoms
Roundworms that were fed a commercially available dietary probiotic showed less buildup of proteins that form during the progression of Parkinson's disease in a new study, published in Cell Reports on January 14. The finding provides further evidence of a link between the gut microbiome and brain function. Read More
Scientists in the Lab: Featuring Rebecca Fleeman
This month, ScienceBoard is featuring scientists in the laboratory to celebrate their important contributions to the scientific community. We are excited to introduce our first featured scientist of this month, Rebecca Fleeman of Penn State College of Medicine in Hershey, PA. Read More
Scientists develop a first-of-its-kind in vitro 3D neural tissue model
Researchers from the University of Illinois at Urbana-Champaign have successfully used stem cells to engineer nerve tissues as 3D models of neural networks to study brain function. The work was published in the December 3 edition of the Proceedings of the National Academy of Sciences. Read More
Scientists identify chaperones as potential therapies for Parkinson's disease
Researchers from the University of Basel have identified the malfunctional relationship and master regulatory mechanisms between chaperone proteins and α-Synuclein occurring in Parkinson's disease. The findings were published in Nature on December 4. Read More
Scientists build artificial neurons to cure chronic disease
Scientists from the University of Bath have achieved a first-of-its-kind artificial neuron on a silicon chip that behaves like a real biological neuron. The technology, published on December 3 in Nature Communications, is intended to cure chronic diseases, such as heart failure or Alzheimer's disease. Read More
New genetic risk factor discovered for Alzheimer's disease
A new genetic risk factor for late-onset Alzheimer's disease (LOAD) has been identified by researchers from the University of Kentucky. The results of the study were published in the Journal of Neuropathology & Experimental Neurology on November 21. Read More
New molecular drivers of Parkinson's disease identified
A group of researchers at the Icahn School of Medicine at Mount Sinai have discovered new molecular drivers of Parkinson's disease (PD) and subsequently determined how they impact the function of genes involved in the disease. This was accomplished using a complex statistical technique called multiscale gene network analysis (MGNA). The results were published in Nature Communications on November 20. Read More
Novel mitochondrial phenomenon helps explains early neurodegeneration
Northwestern University Feinberg School of Medicine scientists discovered a novel pathway that leads to neurodegeneration in amyotrophic lateral sclerosis (ALS). The study was published in Frontiers in Cellular Neuroscience on November 7. The pathway could explain the development of early stages of neurodegeneration which affects voluntary muscle movement such as walking and talking. Read More
Night gardeners: Microglia involved in brain plasticity during sleep
Research from the University of Rochester Medical Center (URMC) suggests that specific immune cells called microglia – which play a crucial role in reorganizing connections between nerve cells, fighting infection, and repairing damage – are primarily active during sleep. The research, conducted on mouse models, was published in Nature Neuroscience on October 21. Read More
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