Antibodies hit drug-resistant cancer cells to improve durability of targeted therapies
Scientists at the Perlmutter Cancer Center at New York University Langone Health have created antibodies designed to target and kill cells that develop resistance to targeted therapies, thereby tackling a barrier to durable anticancer effects. Read More
Mechanistic link between mutation, brain cancer opens up R&D opportunities
Researchers have identified the mechanisms that mean people with a single nucleotide polymorphism have an increased risk of a subtype of brain tumors. Read More
Tumor-promoting mutation linked to suppression of anticancer immune response
Mutations that support the growth of tumor cells may also inhibit T cells, preventing the immune system from responding effectively to emerging cancers, according to Harvard Medical School researchers. Read More
Nanoparticles enhance effect of brain stimulation on stroke recovery in rats
Combining nasally administered nanoparticles and noninvasive brain stimulation improves the recovery of ischemic stroke in rats, according to researchers from Xi’an Jiaotong-Liverpool University and other universities in China. Read More
Biotech licenses drug discovery platform from Harvard, Tufts to study complex CNS diseases
Unravel Biosciences has licensed a drug discovery platform from Harvard University and Tufts University to decode and model complex central nervous system (CNS) diseases. Read More
CRISPR edited rat embryos reveal cause of rare pediatric neurodegenerative disease
Using CRISPR gene editing technology on rat embryos, University of Wisconsin-Madison researchers have revealed the mutation that is responsible for progressive gait abnormalities and other symptoms in human infants and young children with a rare neurodegenerative disease. Read More
New AI tool discovers mutations linking bladder cancer to tobacco smoking
Using a new artificial intelligence (AI) tool, University of California, San Diego researchers contend they have for the first time uncovered a pattern of DNA mutations that links bladder cancer to tobacco smoking. Read More
NIH funds repurposing of breast cancer drug against glioblastoma
The National Institutes of Health (NIH) is funding research into the repurposing of the breast cancer drug letrozole for use against the most deadly form of brain tumors. Read More
Mutated mitochondrial microprotein linked to increased risk of Alzheimer’s
University of Southern California researchers have linked a mitochondrial DNA variant to increased risk of Alzheimer’s disease, pointing to a new way to tackle the hard-to-treat condition. Read More
Combination therapy improves survival in mice with deadly glioblastoma
Combining an antidepressant and vascular endothelial growth factor inhibitor improves outcomes in mouse models of a hard-to-treat type of brain cancer, despite neither treatment being efficacious as a single agent, according to new research. Read More
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