Cancer & Disease Research
Biologically active molecules in coal are found to have antiviral properties against tick-borne encephalitis
Scientists from Russia demonstrated in a Scientific Reports article published on August 19, that biologically active molecular components of substances extracted from coal, humic substances, have antiviral properties. A novel approach to identify these molecules determined that these molecules inhibit the reproduction of tick-borne encephalitis virus (TBEV), which causes clinically relevant human viral infectious disease.  Discuss
The Parkinson’s Foundation launches large-scale genetic study, aiming to improve patient care and speed clinical trials
More than 10 million people worldwide are currently living with Parkinson’s disease (PD), a neurodegenerative disorder that impacts the dopamine-producing neurons in the brain. Scientists do not know exactly what causes PD, but they believe it is a combination of genetic and environmental factors. Nearly 10% to 15% of all PD cases are caused by genetic mutations. A new study aims to understand how the disease develops and how it can be treated or cured. This study, PD GENEration: Mapping the Future of Parkinson’s Disease is currently being conducted by the Parkinson’s Foundation.  Discuss
Detecting HPV in women is improved with the aid of a new molecular approach
A new technique called HPV RNA-Seq can provide a second-line test in HPV-positive patients to reduce unnecessary colposcopies and even be used as a two-in-one test combining HPV typing with triage capabilities. Researchers from Institut Pasteur and the Pathogen Discovery Laboratory in Paris, France published their findings in The Journal of Molecular Diagnostics on August 12, 2019.  Discuss
Thermally stable TB vaccine may now be possible thanks to an innovative new process
Researchers at the University of Bath have developed a process that protects vaccines from heat damage by trapping them in silica cages. The results were published in Scientific Reports on August 8, 2019. Using a leading candidate in the development on new vaccines, Ag85b in conjunction with adjuvant Sbi-Ag85b, thermal stability of tested using a novel process called ensilication.  Discuss
A novel approach to using CRISPR: curing cystic fibrosis
Researchers are finding innovative ways to utilize CRISPR technology to permanently cure diseases, in this case, cystic fibrosis. A collaboration between the University of Trento in Italy and KU Leuven in Belgium, funded by Fondazione ricerca fibrosi cistica led to the publication of a new study in Nature Communications on August 7, 2019.  Discuss
New immunotherapy moves further into clinical testing with promising results
Success in international clinical trials leads to U.S. based research organizations beginning phase I/II clinical trials. If this form of immunotherapy is successful and deemed safe, then it could save the lives of liver cancer patients across the world.  Discuss
Visualizing big data in the life sciences gets an upgrade with new software
A new software developed by researchers at the Max Delbrück Center for Molecular Medicine (MDC) uses algorithms to reconstruct and scale data acquired by light-sheet microscopy that renders a supercomputer unnecessary. Light microscopy techniques provide extremely detailed information but result in terabytes of data which is nearly impossible for scientists to process. MDC researchers are helping make sense of this data.  Discuss
Structure-based vaccine design may help save the lives of infants and children
A new experimental vaccine, utilizing structure-based design, shows promise in a phase I clinical trial. The vaccine will protect against respiratory syncytial virus (RSV), a leading cause of infectious disease deaths in infants. Researchers at the University of Texas at Austin published findings on Aug 2, 2019 in Science stating that one dose elicited increases in RSV-neutralizing antibodies over several months.  Discuss
A bright new tactic in the fight against cardiovascular disease
A new system using reporter proteins has been developed by researchers at Carnegie, Johns Hopkins University, and the Mayo Clinic that uses high-throughput genetic and small-molecule screening, as well as whole-organism imaging to find new drugs for the treatment of cardiovascular disease. These results which provide insights into heart disease were published in Nature Communications on July 31, 2019.  Discuss
Functionality of small protein determined - potential to develop new therapies for Parkinson’s disease
A small protein, alpha-synuclein, has been found to be associated with the prevention of Parkinson’s disease. Scientists at Oregon Health & Science University (OSHU) published results in the journal Scientific Reports on July 29, 2019 showing that alpha-synuclein has a role in repairing breaks in DNA.  Discuss
Conferences
BioProcess International Europe
July 13-17
Central European Time Zone (CET) Netherlands
2020 ACCP Annual Meeting
September 20-22
Bethesda, Maryland United States
Bioprocess International West
September 21-24
Eastern Standard Time Zone (EST) United States
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