Biochemistry
New study offers hope for short-circuiting KRAS-driven lung cancers
The protein kinase p38α has been identified as a key element supporting KRAS-driven lung cancers, so inhibiting the protein has potential as a target for the treatment of certain lung cancers. An international group of researchers used genetic mouse models with the KRAS mutation to observe how p38α inhibition reduces tumor growth. The work was published in the Proceedings of the National Academy of Sciences on January 22.  Discuss
Scientists in the Lab: Featuring Lisa Mustachio
Continuing our feature series this January, ScienceBoard is happy to highlight the work of laboratory scientists, including Lisa Maria Mustachio, PhD, a postdoctoral fellow at MD Anderson Cancer Center.  Discuss
Bacterial evolution reveals method to fight antibacterial resistance
Different types of bacteria have evolved to develop unique mechanisms for achieving the same antibacterial function -- a finding that could lead to new ways to combat antibacterial resistance, according to scientists from Trinity College Dublin. They tested their findings using methicillin-resistant Staphylococcus aureus in a study that was published in Nature Communications on January 9.  Discuss
Researchers elucidate mechanotransduction pathways of transmembrane proteins
Researchers from Imperial College London, Queen Mary University of London, and Tampere University in Finland present new mechanistic pathways for transmembrane proteins with implications in drug discovery and development. The results of the study were published in Nature Materials on January 6.  Discuss
New drug target identified in malaria transmission
Australian researchers from the University of Melborne and Griffith University in Queensland have confirmed their findings of a new drug target that blocks the transmission of Plasmodium falciparum in mosquitos. The results were published in Cell Reports on December 17.  Discuss
Single-molecule resolution technique allows researchers to quantify secondary transport
St. Jude researchers from Columbia University and New York State Psychiatric Institute present new evidence about the mechanics of how secondary active transporter proteins function. This report is published in Nature on November 13.  Discuss
New research suggests circular RNAs are important for cardiac healing
Researchers from the Lewis Katz School of Medicine at Temple University describe how circular RNA fills a critical role during tissue repair after heart attacks, due to a unique ability to absorb harmful molecules. The study was published September 20 in Nature Communications.  Discuss
Breakthrough electrochemical technique may bring cost savings to drug companies
Researchers have developed a simple new method for the creation of hindered ether compounds, which are often important components of many drugs and commercial products. Hindered ethers have been traditionally difficult to manufacture, but scientists at Scripps Research have published a new electrochemistry technique in Nature on September 9, which allows these compounds to be produced faster and more efficiently.  Discuss
Oncogene identified as a therapeutic target for liver cancer
The function of an enzyme that is highly expressed in many cancers has been revealed to regulate key pathways in cancer metabolic adaptation. Researchers at the Georgia Cancer Center and Medical College of Georgia at Augusta University published their findings in Hepatology.  Discuss
Large-scale analysis of microbiome reveals new classes of small proteins with implications in drug discovery
Trillion of bacteria reside within our bodies, and scientists are just scratching the surface of understanding the microbiome. Researchers at Stanford School of Medicine have shed light on previously unidentified proteins that may have an important role in human health and advance drug development.  Discuss
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Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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Conferences
Society for Laboratory Automation and Screening (SLAS) 2020
January 25-29
San Diego, California United States
American Society for Microbiology (ASM) Biothreats
January 28-30
Arlington, Virginia United States
Festival of Genomics 2020
January 29-30
London, Greater London United Kingdom
Medlab Middle East
February 3-6
Dubai, Dubai United Arab Emirates
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